OCT/LCT monitoring of drug action on the structure of the human cornea in vivo

Elina A. Genina (Login required)
N.G. Chernyshevsky Saratov State University, Russia,
Tomsk State University, Russia

Alexey N. Bashkatov
N.G. Chernyshevsky Saratov State University, Russia,
Tomsk State University, Russia

Ivan D. Kamenskikh
V.I. Razumovsky Saratov State Medical University, Russia

Igor O. Kolbenev
V.I. Razumovsky Saratov State Medical University, Russia

Tatiana G. Kamenskikh
V.I. Razumovsky Saratov State Medical University, Russia

Valery V. Tuchin
N.G. Chernyshevsky Saratov State University, Russia,
Tomsk State University, Russia,
Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov, Russia

Paper #1989 received 2014.12.17; revised manuscript received 2015.01.21; accepted for publication 2015.01.21; published online 2015.03.28.

DOI: 10.18287/jbpe-2015-1-1-77


The effect of anti-glaucoma medicinal prepaprations Timolol-AKOS and Cosopt on the structure components of human eye cornea are studied. The eye drops Timolol-AKOS 0.5% and Cosopt were used as the object of study. 10 voluntary patients of the Eye Disease Clinic aged from 70 to 75 suffering from glaucoma took part in the studies. The study of cornea in vivo was carried out using the methods of laser scanning confocal tomography (LCT) and optical coherence tomography (OCT) before the application of drugs and at different time moments after the application. The eye cornea thickness values measured using the OCT at the initial moment of time and at different times after the application of the medicinal preparations are presented. From the LCT data the density and the mean diameter of the cornea epithelial cells was calculated. As a result of the complex studies carried out, it was shown that the Timolol-AKOS medication causes the swelling of the cornea within the limits of 1-5%. Under the use of Cosopt medication the cornea dehydration was observed.


Glaucoma; cornea; optical coherence tomography; confocal microscopy

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