Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Elina A. Genina (Login required)
N.G. Chernyshevsky Saratov State University, Russia,
Tomsk State University, Russia

Alexey N. Bashkatov
N.G. Chernyshevsky Saratov State University, Russia,
Tomsk State University, Russia

Yury P. Sinichkin
N.G. Chernyshevsky Saratov State University, Russia

Irina Yu. Yanina
V.I. Razumovsky Saratov State Medical University, Russia

Valery V. Tuchin
N.G. Chernyshevsky Saratov State University, Russia
Tomsk State University, Russia
Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov, Russia


Paper #1992 received 2014.12.26; revised manuscript received 2015.02.03; accepted for publication 2015.02.05; published online 2015.03.28.

DOI: 10.18287/jbpe-2015-1-1-22

Abstract

A review of specific features and methods of optical clearing and related interaction of light with biotissues is presented. Physical and molecular mechanisms of immersion, compression, and photodynamic/photothermal optical clearing of some fibrous and cellular biotissues are discussed. The possibility of efficient control of the biotissue optical properties, particularly, the reduction of light scattering in biotissues is demonstrated, which facilitates the increased efficiency of various optical visualisation methods (optical biopsy) used in medical purposes

Keywords

tissue; optical clearing; optical methods of diagnostics; visualization

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