Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

Jiasong Li
Department of Biomedical Engineering, University of Houston, TX, USA

Chih-Hao Liu
Department of Biomedical Engineering, University of Houston, TX, USA

Alexander Schill
Department of Biomedical Engineering, University of Houston, TX, USA

Manmohan Singh
Department of Biomedical Engineering, University of Houston, TX, USA

Achuth Nair
Department of Biomedical Engineering, University of Houston, TX, USA

Valery P. Zakharov
Department of Laser and Biotechnical Systems, Samara State Aerospace University, Russia

Kirill V. Larin (Login required)
Department of Biomedical Engineering, University of Houston, TX, USA
Department of Laser and Biotechnical Systems, Samara State Aerospace University, Russia
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA


Paper #2809 received 2015.12.10; revised manuscript received 2015.12.25; accepted for publication 2015.12.30; published online 2016.02.01.

DOI: 10.18287/JBPE-2015-1-4-229

Abstract

Purpose: Elastography is an emerging method for detecting the pathological changes in tissue biomechanical properties caused by various diseases. In this study, we have compared two methods of noncontact optical elastography for quantifying Young’s modulus of tissue-mimicking agar phantoms of various concentrations: a laser Michelson interferometric vibrometer and a phase-stabilized swept source optical coherence elastography system. Methods: The elasticity of the phantoms was estimated from the velocity of air-pulse induced elastic waves as measured by these two techniques. Results: The results show that both techniques were able to accurately assess the elasticity of the samples as compared to uniaxial mechanical compression testing. Conclusion: The laser Michelson interferometric vibrometer is significantly more cost-effective, but it cannot directly provide the elastic wave temporal profile, nor can it offer in-depth information.

Keywords

optical coherence elastography; optical coherence tomography; laser Michelson interferometric vibrometer; elasticity; elastic wave; air-pulse; non-contact

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