Photosensitizing properties of supramolecular systems based on chlorin e6
Paper #3122 received 2016.11.20; accepted for publication 2016.12.29; published online 2016.12.31.
The novel supramolecular systems based on chlorine e6 (Ce6) are presented, and their optical absorption and fluorescence have been investigated. The influence of different excipients as poly-N-vinylpyrrolidone (PVP), polyethyleneglycol (PEG), bovine serum albumin (BSA), chitosan, Triton X-100 (TX-100) on spectral characteristics of these systems has been studied. The obtained spectral-fluorescence characteristics of Ce6-PVP, Ce6-PEG, Ce6-BSA, Ce6-TX-100 indicate disaggregation of chlorine e6 molecules and their consecutive interaction with excipients in solutions and formation of molecular associates and molecular complexes. The system Ce6-chitosan is characterized by aggregation of pigments in solution that reduces photochemical activity of a photosensitizer. The fluorescence quantum yield jk of mentioned above supramolecular systems has been calculated. The results can be useful during the new method of controlled aggregation of photosensitizers as a part of supramolecular complexes development as well as for the purposes of new medicines of predictable photodynamic activity creation.
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