Monte Carlo simulation of skin multispectral autofluorescence

Anastasia O. Ustinova
Samara National Research University, Russia

Ivan A. Bratchenko
Samara National Research University, Russia

Dmitry N. Artemyev orcid (Login required)
Samara National Research University, Russia


Paper #3326 received 2 May 2019; revised manuscript received 8 Jun 2019; accepted for publication 15 Jun 2019; published online 30 Jun 2019.

DOI: 10.18287/JBPE19.05.020306

Abstract

This work is devoted to the simulation of human skin autofluorescence in different spectral ranges. Analytical review was performed for selecting the main endogenous fluorophores with the greatest contribution to the skin fluorescence: tryptophan, tyrosine, collagen, melanin, elastin, lipofuscin, protoporphyrin IX, NADH, FAD. It was necessary to set parameters for autofluorescence modeling, such as the absorption/emission spectra of fluorophores, molar concentration, molar extinction coefficient, and quantum yield. The six-layer skin model was designed in the TracePro software and autofluorescence was simulated when excited at different wavelengths in the middle UV (270-300 nm), near UV (330-360 nm) and visible (400-450 nm) spectral ranges. The simulation results were compared with the experimental results of other authors. The principal distinctive factor of this work is the simulation of the human skin autofluorescence excited in different spectral ranges.

Keywords

autofluorescence; Monte Carlo modeling; skin model; skin fluorophores; optical diagnostics

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References


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