Optical Clearing of the Gastric Mucosa Using 40%-glucose Solution

Vadim D. Genin (Login required)
Saratov State University, Russia

Elina A. Genina
Saratov State University, Russia
Tomsk State University, Russia

Sergey V. Kapralov
Engels City Clinical Hospital No. 1, Engels, Saratov Region, Russia

Veniamin A. Grishaev
Saratov City Clinical Hospital No. 6 named after Acad. Koshelev, Russia

Valery V. Tuchin
Saratov State University, Russia
Tomsk State University, Russia
Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov, Russia

Ekaterina N. Lazareva
Saratov State University, Russia
Tomsk State University, Russia

Alexey N. Bashkatov
Saratov State University, Russia
Tomsk State University, Russia


Paper #3327 received 16 Jul 2019; revised manuscript received 14 Sep 2019; accepted for publication 21 Sep 2019; published online 30 Sep 2019.

DOI: 10.18287/JBPE19.05.030302

Abstract

The kinetics of collimated transmittance of the gastric mucosa under the action of an aqueous 40%-glucose solution was experimentally investigated. Based on the analysis of the transmittance kinetics, the value of the effective diffusion coefficient of glucose in the gastric mucosa was estimated and amounted to (1.59±0.96)×10-6 cm2/s. The permeability coefficient of the mucosa for glucose, calculated using the first Fick diffusion law, was estimated as (2.81±0.90)×10-5 cm/s. It was shown that the introduction of the glucose solution into the mucosa reduced the light scattering coefficient by approximately 5–10%. The increase in the depth of light penetration was from 5% to 15%, depending on the selected spectral range. The results can be used to develop new methods of diagnosis and treatment of stomach diseases.

Keywords

glucose; diffusion coefficient; permeability coefficient; light penetration depth; gastric mucosa; optical clearing

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