Changes in the Structure of the Benzylpenicillin Sodium Salt Molecule under the Pulsed Magnetic Field

Natalia A. Rodenko (Login required)
Samara National Research University, Russia
Samara Federal Research Centre of the Russian Academy of Sciences, Russia

Valentina A. Zhukova
Samara National Research University, Russia

Tatyana I. Vasilieva
Samara National Research University, Russia

Vladimir A. Glushchenkov
Samara National Research University, Russia
Samara Federal Research Centre of the Russian Academy of Sciences, Russia

Irina A. Belyaeva
Samara National Research University, Russia
Samara Federal Research Centre of the Russian Academy of Sciences, Russia


Paper #3387 received 15 Dec 2020; revised manuscript received 31 Jan 2021; accepted for publication 18 Mar 2021; published online 31 Mar 2021.

DOI: 10.18287/JBPE21.07.010305

Abstract

The study aims at the Fourier spectra of an antibiotic exposed to a high-intensity pulsed magnetic field. The applied frequency was f = 40 kHz, with a number of pulses n = 1, at intensities of the pulsed magnetic field H = 0.09 × 106 А/m, Н = 0.50 × 106 А/m, Н = 0.82 × 106 А/m. It was assumed that under the conditions of the pulsed magnetic field there might be a change in the structure of the drug molecule. The research has revealed that an increase in the pulsed magnetic field power leads first to a decrease in the intensity of the band in the Fourier spectrum, and then to its increase. In addition, changes were recorded in the amide group of benzylpenicillin sodium salt molecules depending on the intensity of the pulsed magnetic field applied to the antibiotic.

Keywords

antibiotic; Fourier spectroscopy; magnetic field intensity; biological activity

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References


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