Porous Silicon Nanoparticles with Rare Earth as Potential Contrast Agents for MRI and Luminescent Probes for Bioimaging

Anastasiya D. Mironova orcid (Login required)
Phys-Bio Institute, National Research Nuclear University “MEPhI”, Moscow, Russia

Yulia V. Kargina orcid
Phys-Bio Institute, National Research Nuclear University “MEPhI”, Moscow, Russia
Faculty of Physics, Lomonosov Moscow State University, Russia

Olga S. Pavlova orcid
Faculty of Physics, Lomonosov Moscow State University, 1 Leninskie Gory, Moscow 119991, Russia
Faculty of Fundamental Medicine, Lomonosov Moscow State University, Russia

Alexander M. Perepukhov orcid
Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia

Igor O. Sobina orcid
Faculty of Physics, Lomonosov Moscow State University, Russia

Victor Yu. Timoshenko orcid
Phys-Bio Institute, National Research Nuclear University “MEPhI”, Moscow, Russia
Faculty of Physics, Lomonosov Moscow State University, Russia


Paper #3477 received 19 Feb 2022; revised manuscript received 4 Apr 2022; accepted for publication 1 May 2022; published online 18 May 2022.

DOI: 10.18287/JBPE22.08.020304

Abstract

Nanoparticles of porous silicon with incorporated europium and gadolinium ions were prepared by using mechanical grinding of electrochemically grown mesoporous silicon films followed with impregnation with rare earth ions from aqueous solutions. The photoluminescence spectroscopy of europium doped porous silicon nanoparticles allowed us to reveal narrow lines associated with the 5D07F4 transitions in Eu3+ ions. Measurements of the proton relaxation in aqueous suspensions of nanoparticles with embedded Gd3+ ions showed an effect of the shortening of both the longitudinal and transverse relaxation times. Potential applications of rare earth doped porous silicon nanoparticles as contrast agents in MRI and fluorescent labels in bioimaging are discussed.

Keywords

nanoparticles; aqueous suspensions; proton relaxation; magnetic resonance imaging; contrast agent

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