Intraoperative Optical Diagnostics of Uterine Microcirculation during Myomectomy

Elena Potapova orcid (Login required)
Orel State University, Russia

Nikolai Polenov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

Karina Zakuraeva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

Valentina Krutikova
Orel State University, Russia

Maria Yarmolinskaya orcid
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

Igor Kogan orcid
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia


Paper #5659 received 8 Feb 2023; accepted for publication 6 Mar 2023; published online 16 Mar 2023.

DOI: 10.18287/JBPE23.09.010307

Abstract

Previous studies have shown that intraoperative optical diagnostics can be used to solve fundamental and applied problems in gynecology. Our article presents results from experimental in vivo intraoperative measurements of endogenous fluorescence and blood perfusion in various sections of the uterus, myometrium, endometrium, myomas, and pseudocapsule in female patients undergoing myomectomy. We found that myomas have different blood supply and fluorescence level at wavelength 365 nm depending on their growth intensity and size, most likely due to collagen accumulation in the extracellular matrix and changes in the vascular architecture. The possibility of laser Doppler flowmetry to assess endometrial perfusion is also demonstrated for investigating the effect of myomas of different types on endometrial tissue blood supply. The results obtained can be used to provide a better understanding of pathological processes in uterine leiomyoma, thus helping physicians to choose treatment strategies.

Keywords

optical methods; fluorescence spectroscopy; laser Doppler flowmetry; gynecology; fibroids; myomectomy

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