Terahertz Spectroscopy of Mouse Blood Serum in the Dynamics of Experimental Glioblastoma

Olga P. Cherkasova; Maria R. Konnikova; Maksim M. Nazarov; Denis A. Vrazhnov; Yury V. Kistenev; Alexander P. Shkurinov

Terahertz Spectroscopy of Mouse Blood Serum in the Dynamics of Experimental Glioblastoma

Olga P. Cherkasova (Login required)
Institute of Automation and Electrometry, Siberian Branch of RAS, Novosibirsk, Russia
Institute of Laser Physics of SB RAS, Novosibirsk, Russia
Institute on Laser and Information Technologies, Branch of the Federal Scientific Research Centre “Crystallography and Photonics” of RAS, Shatura, Russia

Maria R. Konnikova
Institute on Laser and Information Technologies, Branch of the Federal Scientific Research Centre “Crystallography and Photonics” of RAS, Shatura, Russia
Lomonosov Moscow State University, Russia
Tomsk State University, Russia

Maksim M. Nazarov
National Research Centre “Kurchatov Institute”, Moscow, Russia

Denis A. Vrazhnov
Tomsk State University, Russia
V. E. Zuev Institute of Atmospheric Optics SB RAS, Tomsk, Russia

Yury V. Kistenev
Tomsk State University, Russia
V. E. Zuev Institute of Atmospheric Optics SB RAS, Tomsk, Russia

Alexander P. Shkurinov
Institute on Laser and Information Technologies, Branch of the Federal Scientific Research Centre “Crystallography and Photonics” of RAS, Shatura, Russia
Lomonosov Moscow State University, Russia
Tomsk State University, Russia

Paper #8990 received 3 Apr 2023; accepted for publication 21 Jun 2023; published online 15 Aug 2023

Abstract

In this study terahertz (THz) absorption spectra of mouse blood serum in the dynamics of experimental U87 glioblastoma were investigated. Decrease of THz absorption with glioma growth was demonstrated. A two-component Debye model was used to analyze the experimental data. Analysis of the complex dielectric permittivity parameters of blood serum indicates an increase in the proportion of bound water in the samples in the dynamics of tumor growth.

Keywords

terahertz time domain spectroscopy; mouse blood serum; U87 glioblastoma; Debye model

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