Low-Coherence Reflectometry and Speckle Polarimetry in the Monitoring of Human Skin Pathologic Changes

Elena M. Artemina (Login required)
Saratov State Medical University named after V.I. Razumovsky, Russia

Sergey A. Yuvchenko
Saratov State Technical University named after Yu.A. Gagarin, Russia

Marina V. Alonova
Saratov State Technical University named after Yu.A. Gagarin, Russia

Dmitry A. Zimnyakov
Saratov State Technical University named after Yu.A. Gagarin, Russia

Sergey R. Utz
Saratov State Medical University named after V.I. Razumovsky, Russia


Paper #3267 received 18 Dec 2017; revised manuscript received 18 Feb 2018; accepted for publication 18 Feb 2018; published online 20 Mar 2018. [Special Section. Workshop “Biophotonics” of the XV all-Russian Youth Samara conference-contest on optics and laser physics].

DOI: 10.18287/JBPE18.04.010501

Abstract

We present the results of the study of normal and pathologic human skin using low-coherence reflectometry and speckle polarimetry. The statistical characteristics of local polarisation states in the individual coherence areas (speckles) of the forward scattered laser radiation demonstrate high sensitivity to the pathologic changes of the biotissue morphology in vitro. The analysis of the attenuation rate of the low-coherence reflectometer signal depending on the probing depth provides additional information for the identification of skin morphologic changes and the analysis of the effect of immersion agents on the biotissue optical properties.

Keywords

surface epidermis strip; polarisation diagnostics of biotissues; optical clearing of biotissues; optical coherence tomography

Full Text:

PDF

References


1. V. V. Tuchin, Handbook of optical biomedical diagnostics, SPIE Press Bellingham, Washington (2016).

2. V. V. Tuchin, Optics of biological tissues. Methods of light scattering in medical diagnostics, FIZMATLIT, Мoscow (2012).

3. D. A. Zimnyakov, M. V. Alonova, E. M. Reshetnikova, E. M. Galkina, S. R. Utz, J. S. Sina, O. V. Angelsky, S. B. Ermolenko, and P. V. Ivashko, “Polarization biopsy in the regime of low forward scattering: a comparative analysis of human skin pathologies,” Problems of optical physics and biophotonics SMF-2013: mater. XVII International. youth. sci. shс. on optics, laser physics and biophotonics, 17-25 (2013).

4. A. Fercher, “Optical coherence tomography – development, principles, applications,” Zeitschrift für Medizinische Physik 20(4), 251-276 (2010). Crossref

5. G. Jarry, E. Steimer, V. Damaschini, M. Epifanie, M. Jurczak, and R. Kaiser, “Coherence and polarization of light propagating through scattering media and biological tissues,” Applied Optics 37(31), 7357-7367 (1998). Crossref

6. J. Briers, “Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging,” Physiological measurement 22(4), R35-R66 (2001). Crossref

7. T. K. Lee, L. Tchvialeva, I. Markhvida, H. Zeng, H. Lui, A. Doronin, I. Meglinski, and D. I. McLean, “Polarization Speckles and Skin Applications,” Imaging in Dermatology, 77-87 (2016). Crossref

8. S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” Journal of Biomedical Optics 7(3), 329-340 (2002). Crossref

9. S. L. Jacques, M. R. Ostermeyer, L. V. Wang, and D. V. Stephens, “Polarized light transmission through skin using video reflectometry: toward optical tomography of superficial tissue layers,” Proceedings of SPIE 2671, 199-211 (1996). Crossref

10. S. R. Utz, S. I. Dovganskiy, and O. D. Odoevskaya, “Use of the method of superficial skin biopsy in dermatological practice,” Vestnik dermatologii i venerologii 7, 37-38 (1992) [in Russian].

11. P. V. Novitsky, and I. A. Zograf, Estimation of errors in measurement results, 2th Edition, Energoatomizdat Publishing House, Leningrad (1991) [in Russian].

12. D. A. Zimnyakov, Yu. P. Sinichkin, P. V. Zakharov, and D. N. Agafonov, “Residual polarization of non-coherently backscattered linearly polarized light: the influence of the anisotropy parameter of the scattering medium,” Waves in Random Media 11(4), 395-412 (2001). Crossref

13. E. M Artemina, S. R. Utz, S. A. Yuvchenko, D. A. Zimnyakov, and M. V. Alonova, “Comparative evaluation of clarifying agents to improve the quality of the far long-wave ultraviolet therapy chronic dermatosis,” Saratov Journal of Medical Scientific Research 12(3), 453-458 (2016) [in Russian]. Crossref






© 2014-2018 Samara National Research University. All Rights Reserved.
Public Media Certificate (RUS). 12+