Optical Biopsy and Optical Pathology: Affordable Health Care Under Low-Resource Settings

Swathi Rao
Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal, Karnataka, India

Reena John
Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal, Karnataka, India

Ajeetkumar Patil
Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal, Karnataka, India

Unnikrishnan V. K.
Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal, Karnataka, India

Sajan D. George
Centre for Applied Nanoscience, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal, Karnataka, India

Keerthilatha M. Pai
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India

Ravikiran Ongole
Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India

Tom Devasia
Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India

V. B. Kartha
Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal, Karnataka, India

Santhosh Chidangil (Login required)
Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal, Karnataka, India


Paper #3377 received 12 Jun 2020; accepted for publication 17 Jun 2020; published online 30 Jun 2020.

DOI: 10.18287/JBPE20.06.020309

Abstract

In this paper the potential of optical spectroscopy based techniques for regular screening and early diagnosis of “Killer” diseases (various types of cancers, cardiovascular diseases, etc.) is discussed with focus on routine use under low-resource settings. A brief account of work carried out in our laboratory to design, assemble and optimize Laser Induced Fluorescence (LIF) based optical devices for routine screening, early diagnosis and discrimination of premalignant/malignant conditions in oral and other cancers is presented. An ultra-sensitive protein profiling system based on highly efficient High Performance Liquid Chromatograpy-Ultrasensitive Laser Induced Fluorescence (HPLC-LIF) detection, and its extensive use in monitoring various cancers, coronary conditions, gynecological problems etc. through protein profile pattern analyses of markers in body fluids is also discussed.

Keywords

optical pathology; laser induced fluorescence; HPLC-LIF; oral cancer; cardio vascular disease; principal component analysis

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