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Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry
Kirill V. Larin
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Department of Biomedical Engineering, University of Houston, TX, USA
Department of Laser and Biotechnical Systems, Samara State Aerospace University, Russia
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA
Paper #2809 received 2015.12.10; revised manuscript received 2015.12.25; accepted for publication 2015.12.30; published online 2016.02.01.
DOI: 10.18287/JBPE-2015-1-4-229
Abstract
Purpose: Elastography is an emerging method for detecting the pathological changes in tissue biomechanical properties caused by various diseases. In this study, we have compared two methods of noncontact optical elastography for quantifying Young’s modulus of tissue-mimicking agar phantoms of various concentrations: a laser Michelson interferometric vibrometer and a phase-stabilized swept source optical coherence elastography system. Methods: The elasticity of the phantoms was estimated from the velocity of air-pulse induced elastic waves as measured by these two techniques. Results: The results show that both techniques were able to accurately assess the elasticity of the samples as compared to uniaxial mechanical compression testing. Conclusion: The laser Michelson interferometric vibrometer is significantly more cost-effective, but it cannot directly provide the elastic wave temporal profile, nor can it offer in-depth information.
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