Ex vivo investigation of glycerol diffusion in skin tissue

Vadim D. Genin; Daria K. Tuchina; Ali Jaafar Sadeq; Elina A. Genina; Valery V. Tuchin; Alexey N. Bashkatov

doi:10.18287/JBPE16.02.010303

Authors

Vadim D. Genin N.G. Chernyshevsky Saratov State University, Russia
Daria K. Tuchina N.G. Chernyshevsky Saratov State University, Russia
Ali Jaafar Sadeq N.G. Chernyshevsky Saratov State University, Russia
Elina A. Genina N.G. Chernyshevsky Saratov State University, Russia Tomsk State University, Russia
Valery V. Tuchin N.G. Chernyshevsky Saratov State University, Russia Tomsk State University, Russia
Alexey N. Bashkatov N.G. Chernyshevsky Saratov State University, Russia Tomsk State University, Russia

DOI:

https://doi.org/10.18287/JBPE16.02.010303

Keywords:

glycerol, diffusion coefficient, skin, optical clearing

Abstract

The change of optical parameters of rat skin ex vivo under the action of aqueous 30%, 50%, 60%, 70%, 85%, and 100% glycerol solutions has been experimentally studied. The analysis of kinetics of the change of the studied parameters has allowed the estimate of the diffusion coefficient dependence upon the concentration of glycerol in the skin and the efficiency of optical clearing for each of the glycerol solutions. The results can find application in the development of new methods of noninvasive diagnostics and therapy of skin diseases.

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ISBN: 9781628415162

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