Ex vivo investigation of glycerol diffusion in skin tissue

Vadim D. Genin (Login required)
N.G. Chernyshevsky Saratov State University, Russia

Daria K. Tuchina
N.G. Chernyshevsky Saratov State University, Russia

Ali Jaafar Sadeq
N.G. Chernyshevsky Saratov State University, Russia

Elina A. Genina
N.G. Chernyshevsky Saratov State University, Russia
Tomsk State University, Russia

Valery V. Tuchin
N.G. Chernyshevsky Saratov State University, Russia
Tomsk State University, Russia

Alexey N. Bashkatov
N.G. Chernyshevsky Saratov State University, Russia
Tomsk State University, Russia


Paper #2933 received 2016.01.19 revised manuscript received 2016.03.10; accepted for publication 2016.03.10; published online 2016.03.29.

DOI: 10.18287/JBPE16.02.010303

Abstract

The change of optical parameters of rat skin ex vivo under the action of aqueous 30%, 50%, 60%, 70%, 85%, and 100% glycerol solutions has been experimentally studied. The analysis of kinetics of the change of the studied parameters has allowed the estimate of the diffusion coefficient dependence upon the concentration of glycerol in the skin and the efficiency of optical clearing for each of the glycerol solutions. The results can find application in the development of new methods of noninvasive diagnostics and therapy of skin diseases.

Keywords

glycerol; diffusion coefficient; skin; optical clearing

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References


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