Time of flight for photon in human skin

Antra Dzerve; Inesa Ferulova; Alexey Lihachev; Janis Spigulis

doi:10.18287/JBPE16.02.030301

Authors

Antra Dzerve Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga, Latvia
Inesa Ferulova Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga, Latvia
Alexey Lihachev Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga, Latvia
Janis Spigulis Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga, Latvia

DOI:

https://doi.org/10.18287/JBPE16.02.030301

Keywords:

absorbtion, light impulse, biophotonics, medical physics

Abstract

The time of flight for photons in human skin was measured using picosecond diode laser. Two different wavelength lasers were used - 405 nm and 510 nm. A difference for time of flight in normal skin and in nevus was observed as well as a difference for different wavelength laser irradiation was observed. For 405 nm laser irradiation the difference was 41 ps while comparison of time of flights skin and nevi using 510 nm irradiation showed a result of 32 ps. Results allow to conclude that the time photon travels in skin might depend on the characteristics of the medium and wavelength of the irradiation. This can be related to known data for light penetration depth in human skin for different wavelengths.

References

R. L. Siegel, K. D. Miller, and A. Jemal, “Cancer statistics, 2016,” A cancer journal for clinicians 66(1), 7-30 (2016).

J. Lesins, A. Lihache, R. Rudys, S. Bagdonas, and J. Spigulis, “Skin autofluorescence photo-bleaching and photo-memory,” Proc. SPIE-OSA 8092, 80920N (2011).

I. Ferulova, A. Lihachev, and J. Spigulis, “Photobleaching effects on in vivo skin autofluorescence lifetime,” J. Biomed. Opt. 20(5), 051031 (2015).

T. Svensson, E. Alerstam, D. Khoptyar, J. Johansson, S. Folestad, and S. Andersson-Engels, “Near-infrared photon time-of-flight spectroscopy of turbid materials up to 1400 nm,” Rev. Sci. Instrum. 80(6), 063105 (2009).

D. Khoptyar, A. A. Subash, S. Johansson, M. Saleem, A. Sparén, J. Johansson, and S. Andersson-Engels, “Broadband photon time-of-flight spectroscopy of pharmaceuticals and highly scattering plastics in the VIS and close NIR spectral ranges,” Optics Express 21(18), 20941-20953 (2013).

J.-C. Bernengo, H. Adhoute, and D. Mougin, “Measurement of the time of flight of photons into the skin: influence of site, age and gender, correlation with other skin parameters,” Skin Research and Technology 21(1), 25-34 (2014).

Safety of Laser Products - Part 1: Equipment Classification and Requirements IEC 60825-1 (2007).

R. R. Anderson, and J. A. Parrish, “The optics of human skin,” Journal of Investigative Dermatology 77(1), 13-19 (1981).

Lesins J., Lihache A., Rudys R., Bagdonas S., and Spigulis J., “Skin autofluorescence photo-bleaching and photo-memory,” Proc. SPIE-OSA 8092, 80920N (2011).

Skin autofluorescence photo-bleaching and photo-memory Janis Lesins, Alexey Lihache, Romualdas Rudys, Saulius Bagdonas, and Janis Spigulis