Mathematical model of skin autofluorescence induced by 450 nm laser

Dmitry N. Artemyev orcid (Login required)
Samara National Research University, Russia


Paper #3293 received 6 May 2018; revised manuscript received 10 Jun 2018; accepted for publication 16 Jun 2018; published online 30 Jun 2018.

DOI: 10.18287/JBPE18.04.020303

Abstract

Optical methods are increasingly being used for the early diagnosis of skin cancer. This approach allows for detecting the component composition changes of tissue in a non-invasive manner. Autofluorescence spectroscopy is a sensitive method for tumor diagnosis and the method availability distinguishes it among other approaches. This work is devoted to fluorescence modeling of skin tissues induced by 450 nm radiation. A multilayer skin model was developed using a set of fluorophores (eumelanin, lipofuscin, riboflavin, beta-carotene, bilirubin) matched with excitation radiation. Model autofluorescence spectra of normal skin tissues of the northern phenotype and pathological changes were obtained. The results were compared with the results of previous experimental studies of ex vivo autofluorescence spectra of the skin and neoplasms.

Keywords

Autofluorescence; Monte Carlo Modeling; Skin Model; Skin Fluorophores; Optical Diagnostics

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