Physical and Biological Properties of Layers with Nanoparticles Based on Metal Chalcogenides and Titanium Synthesized by Femtosecond Laser Ablation and Fragmentation in Liquid

Ulyana E. Kurilova
Vladimir State University, Russia
I. M. Sechenov First Moscow State Medical University, Russia
National Research University of Electronic Technology, Zelenograd, Moscow, Russia

Anton S. Chernikov
Vladimir State University, Russia

Dmitry A. Kochuev
Vladimir State University, Russia

Lidiya S. Volkova
Institute of Nanotechnology of Microelectronics of the Russian Academy of Sciences, Moscow, Russia

Anna A. Voznesenskaya
Vladimir State University, Russia

Ruslan V. Chkalov
Vladimir State University, Russia

Dmitriy V. Abramov
Vladimir State University, Russia

Alexander V. Kazak
Vladimir State University, Russia
Moscow Polytechnic University, Russia

Irina A. Suetina
National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N.F. Gamaleya, Moscow, Russia

Marina V. Mezentseva
National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N.F. Gamaleya, Moscow, Russia

Leonid I. Russu
National Research Center for Epidemiology and Microbiology Named after the Honorary Academician N.F. Gamaleya, Moscow, Russia

Alexander Yu. Gerasimenko
National Research University of Electronic Technology, Zelenograd, Moscow, Russia
I.M. Sechenov First Moscow State Medical University, Russia

Kirill S. Khorkov orcid (Login required)
Vladimir State University, Russia


Paper #3587 received 21 Jan 2023; revised manuscript received 24 Mar 2023; accepted for publication 10 Apr 2023; published online 3 May 2023.

DOI: 10.18287/JBPE23.09.020301

Abstract

In this paper, we present the physical properties and toxicological assessment of layers with nanoparticles based on metal chalcogenides and titanium on human fibroblast cells. Nanoparticles layers based on metal chalcogenides (MoS2, WS2, ZnS) and titanium were applied onto substrate by spray deposition method. Nanoparticles and flakes were synthesized by laser ablation and fragmentation in liquid by femtosecond pulses. We investigated the size and morphology of the synthesized nanoparticles: WS2-based flakes have a polygonal shape with dimensions up to 600 nm, other types of nanoparticles have a shape closer to spherical with sizes from 50 to 150 nm. Interaction of ultrafast laser radiation with materials in liquid is accompanied by the dissociation of water molecules leads to formation of hydrogen sulfide and oxides. To assess the biocompatibility of layers with synthesized nanoparticles, the MTT assay was performed with fibroblast cells. According to in vitro studies, Ti-based nanoparticles have the largest biocompatibility, and WS2-based flakes have the smallest ones. Thus, synthesized Ti-based nanoparticles can be used in biomedical applications to support tissue regeneration without additional modification. Due to their properties, metal sulfides-based nanoparticles can be used in the photodynamic therapy of oncological diseases to destroy cancer cells.

Keywords

metal chalcogenides; pulsed laser ablation in liquid; pulsed laser fragmentation; nanoparticles; toxicity; theranostics; targeted drug delivery; biological markers

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