Enhanced Optical Imaging of Proximal Human Interphalangeal Joints Using Skin Optical Clearing

Elina A. Genina (Login required)
Saratov State University, Russian Federation
Tomsk State University, Russian Federation

Ekaterina A. Kolesnikova
Saratov State University, Russian Federation

Viacheslav G. Artyushenko
art photonics GmbH, Berlin, Germany

Evgeny Berik
Estla Ltd, Lasers & Laser Systems, Tartu, Estonia

Valery V. Tuchin
Saratov State University, Russian Federation
Tomsk State University, Russian Federation
Institute of Precise Mechanics and Control, FRC “Saratov Scientific Centre of the Russian Academy of Sciences”, Saratov, Russian Federation


Paper #9101 received 17 Apr 2024; revised manuscript received 20 Aug 2024; accepted for publication 21 Aug 2024; published online 20 Sep 2024

DOI: 10.18287/JBPE24.10.040303

Abstract

In this study we have analyzed the change in the intensity distribution of three-wavelength transillumination images of human interphalangeal joints under the action of the optical clearing agent. RheumaSens medical scanner prototype with the following wavelengths: 660, 850, and 905 nm, has been tested. A water solution of glycerol (70%) and DMSO (5%) has been used as an optical clearing agent, and sonophoresis has been applied for enhance of skin permeability. Eight healthy volunteers and a volunteer with rheumatoid arthritis have been investigated. As a result, we have obtained an increase in the contrast of joint images within 10 min: 1.2±0.14, 1.16±0.15, and 1.16±0.02 folds at the wavelengths of 660, 850, and 905 nm, respectively. It has been shown an effect of skin optical clearing on the enhancement of the images of joint with rheumatoid arthritis in the transillumination mode.

Keywords

optical clearing; laser transillumination; optical imaging; proximal interphalangeal joints; rheumatoid arthritis

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References


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