Light Dose and Fluorescence Imaging Depth in Dual-Wavelength PDT: a Numerical Study for Various Photosensitizer Distributions in a Layered Biotissue
Daria Kurakina
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A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russian Federation
Paper #9186 received 25 Oct 2024; revised manuscript received 27 Nov 2024; accepted for publication 29 Nov 2024; published online 27 Dec 2024.
DOI: 10.18287/JBPE24.10.040318
Abstract
Dual-wavelength photodynamic therapy (PDT) in combination with fluoescence monitoring has great potential in medical applications, in particular, in the treatment of skin diseases. In this study we conducted numerical Monte Carlo experiments in a two-layer skin model to simulate the absorbed light dose distribution for PDT with chlorin-based photosensitizers as well as to estimate the fluorescence imaging depth depending on the probing radiation wavelength and the photosensitizer (PS) in-depth distribution. The obtained dependencies provide a detailed overview of the light absorption profile and fluorescence signal formation for different PS distribution in layered biotissues, and can be used in various fluorescence based light dosimetry techniques.
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