Optimized Classification with CBGRU-CapNet on Thermographic Analysis to Detect Diabetic Foot Ulcers with Precise Diagnosis

Ashok Babu Ane (Login required)
P.V.P Siddhartha Institute of Technology, Vijayawada, Andhra Pradesh, India

Gireesh Babu C N
BMS Institute of Technology & Management, Bengaluru, Karnataka, India

Karthik Govindan Manoharan
Vellore Institute of Technology, Tamil Nadu, India

Rafeeq MD
CMR Engineering College, Hyderabad, Telangana, India

Bhupathi Rajarao
Eluru College of Engineering and Technology, Andhra Pradesh, India

Kadiyala Vijaya Kumar
G. Pullaiah College of Engineering
and Technology, Kurnool, Andhra Pradesh, India


Paper #9198 received 12 Dec 2024; revised manuscript received 18 Feb 2025; accepted for publication 25 Feb 2025; published online 30 Mar 2025.

DOI: 10.18287/JBPE25.11.010306

Abstract

Diabetic foot ulcers (DFUs) are a severe complication of diabetes mellitus, often leading to lower limb or foot amputation due to infections and a high recurrence rate. Recent research focuses on early detection of underlying conditions that cause skin and tissue damage before visible lesions appear by analysing infrared thermograms of the plantar aspect of both feet. Most existing studies rely on the publicly available INAOE dataset, which includes thermographic images of both healthy and diabetic subjects. However, advancements in the field have been supported by the newly released STANDUP dataset, which offers a more extensive and diverse collection of thermograms. This study utilizes a broader dataset to improve DFU classification. Features are extracted from preprocessed input data using both statistical methods and deep feature extraction techniques. A novel deep learning model, CBGRU-CapNet − combining convolutional layers, bidirectional gated recurrent units (BiGRU), and capsule networks − is employed for classification. To enhance accuracy and reduce computational complexity, the study introduces a fine-tuning approach using the Modified Directional Transport Metaheuristic Algorithm (mDTMA). Experimental results demonstrate that the proposed model achieves superior predictive performance and robustness, making it highly suitable for accurate and consistent DFU detection across multiple evaluation metrics. The results demonstrate that the proposed model provides superior predictive power and robustness, indicating its suitability for tasks requiring high accuracy besides consistency across multiple estimation metrics

Keywords

Diabetic foot ulcer; thermography; directional transport metaheuristic algorithm; bidirectional gated recurrent units; deep features; Diabetes mellitus

Full Text:

PDF

References


1. J. Reyes-Luévano, J. A. Guerrero-Viramontes, J. Rubén Romo-Andrade, and M. Funes-Gallanzi, “DFU_VIRNet: A novel Visible-InfraRed CNN to improve diabetic foot ulcer classification and early detection of ulcer risk zones,” Biomedical Signal Processing and Control 86, 105341 (2023).

2. S. K. Das, P. Roy, P. Singh, M. Diwakar, V. Singh, A. Maurya, S. Kumar, S. Kadry, and J. Kim, “Diabetic foot ulcer identification: A review,” Diagnostics 13(12), 1998 (2023).

3. A. Alqahtani, S. Alsubai, M. P. Rahamathulla, A. Gumaei, M. Sha, Y.-D. Zhang, and M. A. Khan, “Empowering foot health: Harnessing the adaptive weighted sub-gradient convolutional neural network for diabetic foot ulcer classification,” Diagnostics 13(17), 2831 (2023).

4. D. G. Armstrong, T.-W. Tan, A. J. M. Boulton, and S. A. Bus, “Diabetic foot ulcers: A review,” JAMA 330(1), 62 (2023).

5. S. Nagaraju, K. V. Kumar, B. P. Rani, E. L. Lydia, M. K. Ishak, I. Filali, F. K. Karim, and S. M. Mostafa, “Automated diabetic foot ulcer detection and classification using deep learning,” IEEE Access 11, 127578–127588 (2023)..

6. C. Cao, Y. Qiu, Z. Wang, J. Ou, J. Wang, A. H. Hounye, M. Hou, Q. Zhou, and J. Zhang, “Nested segmentation and multi-level classification of diabetic foot ulcer based on mask R-CNN,” Multimedia Tools and Applications 82(12), 18887–18906 (2023).

7. O. Niță, L. I. Arhire, L. Mihalache, A. D. Popa, G. Niță, A. Gherasim, and M. Graur, “Evaluating classification systems of diabetic foot ulcer severity: A 12-Year retrospective study on factors impacting survival,” Healthcare 11(14), 2077 (2023).

8. E. Tamir, O. Rabau, Y. Beer, Y. Smorgick, H. Kaufman, and A. S. Finestone, “A novel classification for diabetic foot ulcers of the first ray,” Advances in Skin & Wound Care 36(1), 30–34 (2023).

9. M. S. A. Toofanee, M. Hamroun, S. Dowlut, K. Tamine, V. Petit, A. K. Duong, and D. Sauveron, “Federated learning: Centralized and P2P for a siamese deep learning model for diabetes foot ulcer classification,” Applied Sciences 13(23), 12776 (2023).

10. P. N. Thotad, G. R. Bharamagoudar, and B. S. Anami, “Diabetic foot ulcer detection using deep learning approaches,” Sensors International 4, 100210 (2023).

11. S. K. Das, S. Namasudra, A. Kumar, and N. R. Moparthi, “AESPNet: Attention enhanced stacked parallel network to improve automatic diabetic foot ulcer identification,” Image and Vision Computing 138, 104809 (2023).

12. B. Gunapriya, T. Rajesh, A. Thirumalraj, and B. Manjunatha, “LW-CNN-based extraction with optimized encoder-decoder model for detection of diabetic retinopathy,” Journal of Autonomous Intelligence 7(3), (2023).

13. M. H. Alshayeji, S. ChandraBhasi Sindhu, and S. Abed, “Early detection of diabetic foot ulcers from thermal images using the bag of features technique,” Biomedical Signal Processing and Control 79, 104143 (2023).

14. K. McDermott, M. Fang, A. J. M. Boulton, E. Selvin, and C. W. Hicks, “Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers,” Diabetes Care 46(1), 209–221 (2023).

15. V. Sathya Preiya, V. D. A. Kumar, “Deep learning-based classification and feature extraction for predicting pathogenesis of foot ulcers in patients with diabetes,” Diagnostics 13(12), 1983 (2023).

16. A. Hernandez-Guedes, N. Arteaga-Marrero, E. Villa, G. M. Callico, and J. Ruiz-Alzola, “Feature ranking by variational dropout for classification using thermograms from diabetic foot ulcers,” Sensors 23(2), 757 (2023).

17. I. Khosa, A. Raza, M. Anjum, W. Ahmad, and S. Shahab, “Automatic diabetic foot ulcer recognition using multi-level thermographic image data,” Diagnostics 13(16), 2637 (2023).

18. S. Biswas, R. Mostafiz, B. K. Paul, K. M. Mohi Uddin, M. M. Rahman, and F. N. U. Shariful, “DFU_MultiNet: A deep neural network approach for detecting diabetic foot ulcers through multi-scale feature fusion using the DFU dataset,” Intelligence-Based Medicine 8, 100128 (2023).

19. M. Bundó, B. Vlacho, J. Llussà, I. Bobé, M. Aivar, C. Ciria, A. Martínez-Sánchez, J. Real, M. Mata-Cases, X. Cos, M. Dòria, J. Viade, J. Franch-Nadal, and D. Mauricio, “Prediction of outcomes in subjects with type 2 diabetes and diabetic foot ulcers in Catalonian primary care centers: a multicenter observational study,” Journal of Foot and Ankle Research 16(1), 8 (2023).

20. T. Lan, Z. Li, and J. Chen, “FusionSegNet: Fusing global foot features and local wound features to diagnose diabetic foot,” Computers in Biology and Medicine 152, 106456 (2023).

21. S. Özgür, S. Mum, H. Benzer, M. K. Toran, and İ. Toygar, “A machine learning approach to predict foot care self-management in older adults with diabetes,” Diabetology & Metabolic Syndrome 16(1), 244 (2024).

22. Y. Chen, Y. Zhang, M. Jiang, H. Ma, and Y. Cai, “HMOX1 as a therapeutic target associated with diabetic foot ulcers based on single-cell analysis and machine learning,” International Wound Journal 21(3), e14815 (2024).

23. S. Hong, Y. Chen, Y. Lin, X. Xie, G. Chen, H. Xie, and W. Lu, “Personalized prediction of diabetic foot ulcer recurrence in elderly individuals using machine learning paradigms,” Technology and Health Care 32, 265–276 (2024).

24. M. Saeedi, H. T. Gorji, F. Vasefi, and K. Tavakolian, “Federated versus central machine learning on diabetic foot ulcer images: Comparative simulations,” IEEE Access 12, 58960–58971 (2024).

25. G. Verma, “Leveraging smart image processing techniques for early detection of foot ulcers using a deep learning network,” Polish Journal of Radiology 89, 368–377 (2024).

26. C. Wu, C. Xu, S. Ou, X. Wu, J. Guo, Y. Qi, and S. Cai, “A novel approach for diabetic foot diagnosis: Deep learning-based detection of lower extremity arterial stenosis,” Diabetes Research and Clinical Practice 207, 111032 (2024).

27. L. Z. Chee, S. Sivakumar, K. H. Lim, and A. A. Gopalai, “Gait acceleration-based diabetes detection using hybrid deep learning,” Biomedical Signal Processing and Control 92, 105998 (2024)..

28. R. Castillo-Morquecho, E. Guevara, J. L. Ramirez-GarciaLuna, M. A. Martínez-Jiménez, M. G. Medina-Rangel, and E. S. Kolosovas-Machuca, “Digital infrared thermography and machine learning for diabetic foot assessment: thermal patterns and classification,” Journal of Diabetes & Metabolic Disorders 23(2), 1967–1976 (2024).

29. D. K. Agrawal, W. Jongpinit, S. Pojprapai, W. Usaha, P. Wattanapan, P. Tangkanjanavelukul, and T. Vitoonpong, “Smart insole-based plantar pressure analysis for healthy and diabetic feet classification: statistical vs. machine learning approaches,” Technologies 12(11), 231 (2024).

30. H. Shi, X. Yuan, X. Yang, R. Huang, W. Fan, and G. Liu, “A novel diabetic foot ulcer diagnostic model: identification and analysis of genes related to glutamine metabolism and immune infiltration,” BMC Genomics 25(1), 125 (2024).

31. A. M. El-Kady, M. M. Abbassy, H. Hamdy, A. Farid, A. Moussa, “Advancing diabetic foot ulcer detection based on resnet and gan integration,” Journal of Theoretical and Applied Information Technology 102(6), 2258–2268 (2024).

32. S. A. Sulayman, A. R. Qishqish, and G. F. Dayhoom, “Early detection of diabetic foot using thermal imaging and deep learning techniques,” African Journal of Advanced Pure and Applied Sciences, 564–567 (2024).

33. A. Sridhar, R. Balasubramanian, J. A. Krishnaswamy, G. Radhakrishnan, and B. Pesala, “Deep-learning aided multispectral autofluorescence imaging for rapid bioburden detection and gram-type classification on diabetic foot ulcers,” Optics and Biophotonics in Low-Resource Settings X 14 (2024).

34. M. Cakir, G. Tulum, F. Cuce, K. B. Yilmaz, A. Aralasmak, M. İ. Isik, and H. Canbolat, “Differential diagnosis of diabetic foot osteomyelitis and charcot neuropathic osteoarthropathy with deep learning methods,” Journal of Imaging Informatics in Medicine 37(5), 2454–2465 (2024).

35. S. Murugan, N. Mohankumar, “Smart foot monitoring: A cutting-edge solution for early detection of diabetic complications using CNN model,” International Journal of Advances in Signal and Image Sciences 10(1), 45–55.

36. D. Bouallal, A. Bougrine, R. Harba, R. Canals, H. Douzi, L. Vilcahuaman, and H. Arbanil, “STANDUP database of plantar foot thermal and RGB images for early ulcer detection,” Open Research Europe 2, 77 (2022).

37. D. A. Hernandez-Contreras, H. Peregrina-Barreto, J. de J. Rangel-Magdaleno, and F. J. Renero-Carrillo, “Plantar thermogram database for the study of diabetic foot complications,” IEEE Access 7, 161296–161307 (2019).

38. N. Arteaga-Marrero, L. C. Bodson, A. Hernández, E. Villa, and J. Ruiz-Alzola, “Morphological foot model for temperature pattern analysis proposed for diabetic foot disorders,” Applied Sciences 11(16), 7396 (2021).

39. E. Villa, N. Arteaga-Marrero, and J. Ruiz-Alzola, “Performance assessment of low-cost thermal cameras for medical applications,” Sensors 20(5), 1321 (2020).

40. R. Aluvalu, T. Sharma, U. M. Viswanadhula, A. D. Thirumalraj, M. V. V. P. Kantipudi, and S. Mudrakola, “Komodo dragon mlipir algorithm-based CNN model for detection of illegal tree cutting in smart IoT forest area,” Recent Advances in Computer Science and Communications 17(6), 1–12 (2024).

41. V. Snášel, L. Kong, and S. Das, “From constraints fusion to manifold optimization: A new directional transport manifold metaheuristic algorithm,” Information Fusion 113, 102596 (2025).






Сontact

34 Moskovskoe shosse, Samara, 443086, Russian Federation
Email: j-bpe@ssau.ru
Phone: +7-846-267-4550
© 2014-2025 J-BPE