Capture and Retention of Polystyrene Microspheres with Biomarkers in Optical and Optothermal Traps
Valeria K. Uryupina
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Lebedev Physical Institute, Samara branch, Russian Federation
Samara National Research University, Russian Federation
Paper #9253 received 3 Mar 2025; revised manuscript received 13 Mar 2025; accepted for publication 21 Mar 2025; published online 16 Apr 2025.
DOI: 10.18287/JBPE25.11.020302
Abstract
The capabilities of optical and optothermal tweezers for manipulating 2-μm polystyrene microspheres with kidney and thyroid antigens are experimentally demonstrated. The ability of arranging such objects in various configurations with subsequent fixation has been demonstrated. It has been shown that the detachment rates of modified polystyrene microspheres depend on the presence and type of antigen. Experiments on optical capture of polystyrene microspheres in a mixed solution of sodium tetraborate with the addition of sodium dodecyl sulfate (SDS) of different molar concentrations are carried out. It is shown that an increase in the molar concentration of SDS from 5 to 30 mM leads to a decrease in the detachment rate by 55%.
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