Experimental Correction of Arbitrary Instrument Functions in Optical Coherence Tomography Using Only Relative Measurements
Alexander A. Sovetsky
A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russian Federation
Alexander L. Matveyev
A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russian Federation
Lev A. Matveev
A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russian Federation
Vladimir Y. Zaitsev
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A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russian Federation
DOI: 10.18287/JBPE25.11.030301
Abstract
One of recent trends in optical coherence tomography (OCT) is the development of various functional modalities beyond straightforward structural imaging. One of such modalities is extraction of optical attenuation coefficient (OAC) from OCT scans. The OAC distributions may be rather informative, however, their extraction from OCT scans can be seriously distorted by the instrument function of OCT setup which may seriously affect the observed depth-dependence of the OCT-signal amplitude. Various procedures for correcting the influence of the instrument function of the OCT setup on the estimated OAC distribution in the sample have been discussed in the literature. To introduce the corresponding correction factors theoretically such procedures, require sufficiently detailed knowledge of the OCT setup parameters. Alternative experimental methods make it possible to obviate the necessity of knowing the OCT-setup parameters, for example, by using a specially prepared calibration phantom with a known value of spatially uniform OAC. In this manuscript we propose an efficient experimental method which is based on exclusively relative measurements, for performing which neither OCT-setup parameters, nor absolute OAC value for the calibration phantom are required. The method makes it possible to correct instrument functions of arbitrary types in either spectral domain or time-domain OCT. Examples of application of the correction method for different OCT-setups are presented to emphasize that the use of uncorrected data may lead to rather strong errors of OAC-distribution estimation in both axial and lateral directions. The proposed method should be helpful to improve the diagnostic accuracy OCT examinations relying on the OAC extraction from OCT data.
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