Modeling of PpIX Fluorescence of a Two Layered Medium: A Monte-Carlo Study

Ali Shahin (Login required)
Al-Ayen Iraqi University, Dhi-Qar, Iraq




DOI: 10.18287/JBPE25.11.040303

Abstract

An advancement of an exponential model of protoporphyrin IX (PpIX) fluorescence of two-layered media has been accomplished to mimic healthy and tumor brain tissues. The optical properties of these layers were selected to mimic meningioma as a tumor tissue and white matter as a healthy tissue at 405 nm excitation and 635 nm emission wavelengths. The media were considered to be homogeneous and the mismatched boundary was not taken into account. Then, the refractive index of these two layers was the same and equal to 1.4. The thickness of the tumor layer turned out to be varied between 0.1 µm and 0.6 cm, and 10 cm thick of the lower normal layer (infinity). Fluorescence was estimated theoretically based on the Monte-Carlo algorithm and fitted to the developed model. Finally, the relative error of the presented model was less than 5%. The simplicity and robustness of the presented model make it a good choice to estimate fluorescence and reproduce the thickness of the upper layer in real-time.

Keywords

Fluorescence; meningioma; Monte Carlo method; PpIX

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