The stress-related changes in the cerebral blood flow in newborn rats with intracranial hemorrhage: metabolic and endothelial mechanisms

Olga Sindeeva; Ekaterina Borisova; Arkady Abdurashitov; Ekaterina Zhinchenko; Artem Gekalyuk; Maria Ulanova; Aly Esmat Sharif; Victoria Razubaeva; Sergey Serov; Ludmila Yankovskaya; Valery V. Tuchin; Oxana Semyachkina-Glushkovskaya

doi:10.18287/JBPE-2015-1-4-248

Authors

Olga Sindeeva National Research Saratov State University, Russia
Ekaterina Borisova Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria
Arkady Abdurashitov National Research Saratov State University, Russia
Ekaterina Zhinchenko National Research Saratov State University, Russia
Artem Gekalyuk National Research Saratov State University, Russia
Maria Ulanova National Research Saratov State University, Russia
Aly Esmat Sharif National Research Saratov State University, Russia
Victoria Razubaeva National Research Saratov State University, Russia
Sergey Serov National Research Saratov State University, Russia
Ludmila Yankovskaya Grodno State Medical University, Belorus
Valery V. Tuchin National Research Saratov State University, Russia Laboratory of Biophotonics, Tomsk State University, Russia
Oxana Semyachkina-Glushkovskaya National Research Saratov State University, Russia

DOI:

https://doi.org/10.18287/JBPE-2015-1-4-248

Keywords:

speckle laser contrast imaging, oxygen saturation, stress-related intracranial hemorrhages, hypoxia, nitric oxide

Abstract

Neonatal brain hemorrhages is a major problem of future generation’s health due to the high rate of cognitive disability of newborns after vascular catastrophes in the brain. Despite the public health impact of neonatal brain hemorrhages, the mechanisms underlying in these pathological processes remain unknown. Here, using a model of sound-stress-induced brain hemorrhages (per diapedesis, no per rhexis) in newborn rats and optical methods, we found that brain hemorrhages in newborn rats are accompanied by the increase in perfusion of brain tissues, which closely associated with reducing of cerebral oxygenation and increasing of nitric oxide production in both the brain tissues and blood. We assume that nitric oxide contributes the dilation of cerebral vessels during hypoxia and the increasing of cerebral blood flow in newborn rats with brain hemorrhages. Hypoxic-hyperperfusion during stress-related hemorrhages in newborn animals can be an important protective mechanism against anoxia and critical changes in cerebral hemodynamics.

Author Biography

Olga Sindeeva, National Research Saratov State University, Russia

Department of Biology, Chair of Human and Animal Physiology, Teaching Assistant

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