Study of immunogenic properties of transmissible gastroenteritis virus antigen conjugated to gold nanoparticles

Pavel V. Mezhenny (Login required)
Saratov State Agrarian University, Russia

Sergej A. Staroverov
IBPPM RAS, Saratov, Russia
Saratov Scientific and Research Veterinary Institute, Russia

Aleksandr S. Fomin
IBPPM RAS, Saratov, Russia
Saratov Scientific and Research Veterinary Institute, Russia

Aleksej A. Volkov
Saratov State Agrarian University, Russia

Ivan Y. Domnitsky
Saratov State Agrarian University, Russia

Sergey V. Kozlov
Saratov State Agrarian University, Russia

Vladislav N. Laskavy
Saratov Scientific and Research Veterinary Institute, Russia

Lev A. Dykman
IBPPM RAS, Saratov, Russia

Paper #3121 received 2016.12.02; accepted for publication 2016.12.29; published online 2016.12.31.

DOI: 10.18287/JBPE16.02.040308


There was performed the study of immunogenic properties of the transmissible gastroenteritis virus antigen conjugated to gold nanoparticles. In comparative immunobiological studies there was found that immunization of guinea pigs driven by the colloidal gold conjugated to transmissible gastroenteritis virus antigen of swine, leads to activation of the respiratory activity of lymphoid cells and peritoneal macrophages, which is directly related to increased activity of antibody-producing cells and activation of antibody generating. The obtained data suggest that the colloid particles promote antigen presentation to the reticuloendothelial system organs. In addition, there was established that these carriers stimulate production of proinflammatory cytokines, which leads to a complete and consistent immune response of both cellular and humoral components of immune system.


Gold Nanoparticles; nanomaterials; transmissible gastroenteritis virus; cytokines

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