Serum albumin molecular mobility in water solutions, containing iron chloride III

Victoria V. Gibizova (Login required)
Department of Physics, M.V. Lomonosov Moscow State University, Russian Federation

Viktor A. Sapozhnikov
Department of Physics, M.V. Lomonosov Moscow State University, Russian Federation

Ksenia V. Fedorova
Department of Physics, M.V. Lomonosov Moscow State University, Russian Federation

Galina P. Petrova
Department of Physics, M.V. Lomonosov Moscow State University, Russian Federation


Paper #3128 received 2016.11.20; accepted for publication 2016.12.29; published online 2016.12.31.

DOI: 10.18287/JBPE16.02.040304

Abstract

The lack or overload of iron in living organism can cause different diseases, including those related to the serum blood. In this connection the basic blood proteins, in particular, albumin, can change their charge, conformation, molecular mobility, etc. Due to this fact, it is of undoubtful interest to study the molecular dynamical processes that occur in water solutions of serum albumin under the effect of iron ions. In the present work we performed comparative studies of optical properties of bovine serum albumin (BSA) water solutions and BSA solutions with the addition of Iron(III) chloride by light scattering.

Keywords

dynamic light scattering; static light scattering; translation diffusion coefficient; hydrodynamic radius; intermolecular interaction coefficient

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References


1. P. T. Lieu, M. Heiskala, P. A. Peterson, and Y. Yang, “The roles of iron in health and disease,” Molecular Aspects of Medicine 22(1–2), 1–87 (2001).

2. Z. Shu-hong, F. Yong-shan, F. Shuo, and Z. Yun-feng, “Microdetermination of proteins by resonance light scattering technique based on aggregation of ferric nanoparticles,” Spectrochimica Acta Part A 72, 748–752 (2008). Crossref

3. B. D. Fair, and A. M. Jamieson, “Effect of Electrodynamic Interactions on the Translational Diffusion of Bovine Serum Albumin at Finite Concentration,” Journal of Colloid and Interface Science 73(1), 130-135 (1980). Crossref

4. M. Othman, A. Aschi, and A. Gharbi, “Polyacrylic acids–bovine serum albumin complexation: Structure and dynamics,” Materials Science and Engineering C. 58, 316-323 (2016). Crossref

5. V. V. Gibizova, I. A. Sergeeva, G. P. Petrova, A. V. Priezzhev, and N. G. Khlebtsov, “Interaction of Albumin and gamma-Globulin Molecules with Gold Nanoparticles in Water Solutions,” Moscow University physics bulletin. 66(5), 449–452 (2011) [in Russian].

6. http://www.photocor.ru/.

7. H. Z. Cummins, and E. R. Pike, Photon Correlation and Light Beating Spectroscopy, Springer Science+Business Media, New York (1974). Crossref

8. A. Einstein, Collected Papers, Nauka, Moscow (1966) [in Russian].

9. V. N. Tsvetkov, B. E. Eskin, and S. Y. Frenkel, Structure of Macromolecules in Solutions, Nauka, Moscow (1964) [in Russian].




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