OCT study of skin optical clearing with preliminary laser ablation of epidermis

Natalia S. Ksenofontova; Elina A. Genina; Alexey N. Bashkatov; Georgy S. Terentyuk; Valery V. Tuchin

doi:10.18287/JBPE17.03.020307

OCT study of skin optical clearing with preliminary laser ablation of epidermis

Natalia S. Ksenofontova (Login required)
Saratov National Research State University, Russia

Elina A. Genina
Saratov National Research State University, Russia
National Research Tomsk State University, Russia

Alexey N. Bashkatov
Saratov National Research State University, Russia
National Research Tomsk State University, Russia

Georgy S. Terentyuk
The First Veterinary Clinic, Saratov, Russia

Valery V. Tuchin
Saratov National Research State University, Russia
Institute of Precision Mechanics and Control, Russian Academy of Sciences, Laboratory of Laser Diagnostics of Technical and Living Systems, Saratov, Russia
Samara National Research University, Russia

Paper #3141 received 3 Mar 2017; revised manuscript received 5 Apr 2017; accepted for publication 5 Apr 2017; published online 27 Apr 2017.

DOI: 10.18287/JBPE17.03.020307

Abstract

We report the results of the experimental study of optical immersion clearing of laboratory animals skin in vivo with preliminary laser ablation of epidermis. It is shown that the ablation of the skin surface leads to the local edema that reduces the optical detection depth immediately after the impact. However, the water evaporation from the damaged epidermis causes the optical clearing of skin, comparable with that caused by polyethylene glycol in intact skin. It is shown that the preliminary ablation of the skin surface before the application of immersion agent does not lead to significant increase of the optical detection depth as compared to the sole effect of ablation or immersion.

Keywords

skin laser ablation; optical coherence tomography; optical detection depth; immersion optical clearing

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