Optical clearing of human dura mater by glucose solutions

Elina A. Genina (Login required)
Saratov National Research State University, Russia
National Research Tomsk State University, Russia

Alexey N. Bashkatov
Saratov National Research State University, Russia
National Research Tomsk State University, Russia

Valery V. Tuchin
Saratov National Research State University, Russia
Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov, Russia
Samara National Research University, Russia


Paper #3177 received 9 Apr 2016; accepted for publication 20 Apr 2017; published online 30 Apr 2017.

DOI: 10.18287/JBPE17.03.010309

Abstract

Significant light scattering by dura mater in the visible spectral range seriously restricts the application of noninvasive optical methods to the diagnostics and therapy of brain diseases. We present the results of the study of human dura mater optical clearing in vitro by the glucose solutions with the concentrations 1.5М and 3М in the spectral range 400-700 nm. The efficiency of the tissue optical clearing is assessed. Basing on the analysis of the kinetics of collimated transmittance of light by samples of dura mater, the relative glucose diffusion coefficients are calculated that amount to (1.1±0.1)´10-6 cm2/s and (2.0±0.2)´10-6 cm2/s, respectively.

Keywords

Optical immersion clearing; Dura mater; Collimated transmittance; Diffusion coefficient

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