Optical Clearing of Human Skin Using Polyethylene Glycols

Kirill V. Berezin; Konstantin N. Dvoretskiy; Vladimir V. Nechaev; Anatoliy M. Likhter; Ilmira T. Shagautdinova; Valery V. Tuchin

doi:10.18287/JBPE20.06.020308

Optical Clearing of Human Skin Using Polyethylene Glycols

Kirill V. Berezin
Saratov State University, Russia

Konstantin N. Dvoretskiy (Login required)
Saratov State Medical University, Russia

Vladimir V. Nechaev
Saratov State Technical University, Russia

Anatoliy M. Likhter
Astrakhan State University, Russia

Ilmira T. Shagautdinova
Astrakhan State University, Russia

Valery V. Tuchin
Saratov State University, Russia
Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov, Russia
Tomsk State University, Tomsk, Russia

Paper #3373 received 23 May 2020; revised manuscript received 11 Jun 2020; accepted for publication 12 Jun 2020; published online 27 Jun 2020.

DOI: 10.18287/JBPE20.06.020308

Abstract

Molecular docking and quantum chemistry (PM6 and DFT/B3LYP) methods have been used to investigate the interaction of a number of biological tissue immersion clearing agents (PEG200, PEG300 and PEG400) with collagen mimetic peptides (GPH)₃. Correlations between the rate (efficiency) of optical clearing and the energy of complex formation are established.

Keywords

molecular dynamics; quantum chemistry; immersion optical clearing

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