Assessing Porcine Iris Elasticity and Mechanical Anisotropy with Optical Coherence Elastography

Christian Zevallos-Delgado
Department of Biomedical Engineering, University of Houston, Houston, TX, USA

Taye T. Mekonnen
Department of Biomedical Engineering, University of Houston, Houston, TX, USA

Fernando Zvietcovich
Department of Biomedical Engineering, University of Houston, Houston, TX, USA

Manmohan Singh
Department of Biomedical Engineering, University of Houston, Houston, TX, USA

Salavat Aglyamov
Department of Mechanical Engineering, University of Houston, Houston, TX, USA

Kirill Larin (Login required)
Department of Biomedical Engineering, University of Houston, Houston, TX, USA


Paper #3443 received 21 Jun 2021; revised manuscript received 7 Sep 2021; accepted for publication 7 Sep 2021; published online 29 Oct 2021.

DOI: 10.18287/JBPE21.07.040304

Abstract

The relaxation and contraction of the sphincter and dilator muscles of the iris play a critical role in vision, yet little is known about the biomechanical properties of these muscles. This study aimed to determine the elastic properties of the iris as a function of its anatomy and intraocular pressure. A high-resolution phase-sensitive OCE system was employed to detect acoustic radiation force induced propagation of elastic waves in the porcine iris in situ. Experiments were conducted at four different intraocular pressures (5, 10, 20, and 30 mmHg) with mechanical excitation at 1 kHz. We found that there was no significant difference in the wave speed at the different intraocular pressures. The results show that the stiffness of the iris was significantly higher in the semi-azimuthal orientation (mean wave speed of 2.5 m/s) than in the radial orientation (mean wave speed of 1.5 m/s). These measurements provide essential insights into the elastic properties of the iris, and they can be used for the characterization of eye conditions.

Keywords

optical coherence elastography; iris; acoustic radiation force; biomechanics; elasticity; Young’s modulus; intraocular pressure

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References


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