Thermomechanical Threshold of Laser Action on the Tympanic Membrane while Maintaining Its Structure

Olga I. Baum (Login required)
National Research Centre “Kurchatov Institute”, Moscow, Russian Federation

Ekaterina M. Kasianenko
National Research Centre “Kurchatov Institute”, Moscow, Russian Federation

Anna V. Zolotova
National Research Centre “Kurchatov Institute”, Moscow, Russian Federation
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Mikhail V. Svistushkin
National Research Centre “Kurchatov Institute”, Moscow, Russian Federation
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Natalia B. Serejnikova
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation




DOI: 10.18287/JBPE25.11.030306

Abstract

Laser-induced modification of the structure and properties of biological tissues is a novel and rapidly advancing approach used for tissue reconstruction without causing destruction or coagulation of the biological material. This work is devoted to determining the threshold values of laser exposure parameters on the tissue of the tympanic membrane (TM) while preserving its integrity and structure. The findings aim to facilitate the extrapolation of principles from established laser-based technologies to new biological tissue types, notably those where cells exist predominantly in a state of normoxia. This work is the first step in the development of a new laser technology − laser regeneration of the TM. In this work, using computer modeling, temperature fields and thermal stress fields, the values of which are close to known values, which have a positive effect on cell proliferation and matrix synthesis, were found. Two laser modes selected for the in vivo experiment made it possible to determine the acceptable range of effects on the TM under conditions of maintaining its integrity and to find the threshold for detachment of the TM epithelium while maintaining the structure of its deeper layers.

Keywords

infrared laser; temperature field; thermomechanical stress; tympanic membrane

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References


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