Lung neoplasm diagnostics using Raman spectroscopy and autofluorescence analysis

Valery P. Zakharov; Ivan A. Bratchenko; Dmitry N. Artemyev; Oleg O. Myakinin; Dmitry V. Kornilin; Sergey V. Kozlov; Alexander A. Moryatov

doi:10.18287/jbpe-2015-1-1-70

Authors

Valery P. Zakharov Laser and biotechnical systems department, Samara State Aerospace University, Russia
Ivan A. Bratchenko Laser and biotechnical systems department, Samara State Aerospace University, Russia
Dmitry N. Artemyev Laser and biotechnical systems department, Samara State Aerospace University, Russia
Oleg O. Myakinin Laser and biotechnical systems department, Samara State Aerospace University, Russia
Dmitry V. Kornilin Laser and biotechnical systems department, Samara State Aerospace University, Russia
Sergey V. Kozlov Oncology Department, Samara State Medical University, Russia
Alexander A. Moryatov Oncology Department, Samara State Medical University, Russia

DOI:

https://doi.org/10.18287/jbpe-2015-1-1-70

Keywords:

Raman spectroscopy, autofluorescence, optical diagnostics for medicine, spectroscopy, tissue diagnostics, lung cancer

Abstract

A method of lung neoplasm diagnostics is proposed based on the combined analysis of Raman and autofluorescence spectra excited by laser beam with the wavelength 785 nm. Such approach allows fast selection of the pathology region followed by differentiation of the neoplasm type. The developed method demonstrated the sensitivity of 90.9% and the specificity of 71.4% in the differentiation of squamous cell carcinoma and adenocarcinoma cases.

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