Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy
DOI:
https://doi.org/10.18287/jbpe-2015-1-1-22Keywords:
tissue, optical clearing, optical methods of diagnostics, visualizationAbstract
A review of specific features and methods of optical clearing and related interaction of light with biotissues is presented. Physical and molecular mechanisms of immersion, compression, and photodynamic/photothermal optical clearing of some fibrous and cellular biotissues are discussed. The possibility of efficient control of the biotissue optical properties, particularly, the reduction of light scattering in biotissues is demonstrated, which facilitates the increased efficiency of various optical visualisation methods (optical biopsy) used in medical purposesReferences
V. V. Tuchin (Ed.), Handbook of Optical Biomedical Diagnostics, SPIE Press, PM107, Bellingham (2002).
T. Vo-Dinh (Ed.), Biomedical Photonics Handbook, CRC Press, Boca Raton, FL, USA (2003); second edition (2014).
V. V. Tuchin, Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis, Bellingham, SPIE Press (2007).
D. A. Boas, “A fundamental limitation of linearized algorithms for diffuse optical tomography,” Opt. Express. 1, 404-413 (1997).
C. L. Smithpeter, A. K. Dunn, A. J. Welch, and R. Richards-Kortum, “Penetration depth limits of in vivo confocal reflectance imaging,” Appl. Opt. 37, 2749–2754 (1998).
V. V. Tuchin, L. V. Wang, and D. A. Zimnyakov, Optical Polarization in Biomedical Applications, Springer-Verlag, New York, NY, USA (2006).
R. Drezek, A. Dunn, and R. Richards-Kortum, “Light scattering from cells: finite-difference time-domain simulations and goniometric measurements,” Appl. Opt. 38(16), 3651–3661 (1999).
K. Sokolov, R. Drezek, K. Gossagee, and R. Richards-Kortum, “Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology,” Opt. Express 5, 302–317 (1999).
D. W. Leonard, and K. M. Meek, “Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma,” Biophysical J. 72, 1382–1387 (1997).
A. G. Borovoi, E. I. Naats, and U. G. Oppel, “Scattering of light by a red blood cell,” J. Biomed. Opt. 3, 364–372 (1998).
A. N. Yaroslavsky, A. V. Priezzhev, J. Rodriguez, I. V. Yaroslavsky, and H. Battarbee, “Optics of blood,” Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, Ed., pp. 169–216, PM107 SPIE Press, Bellingham, WA, USA (2002).
G. Mazarevica, T. Freivalds, and A. Jurka, “Properties of erythrocyte light refraction in diabetic patients,” J. Biomed. Opt. 7, 244–247 (2002).
M. Friebel, and M. Meinke, “Model function to calculate the refractive index of native hemoglobin in the wavelength range of 250–1100 nm dependent on concentration,” Appl. Opt. 45(12), 2838–2842 (2006).
E. Gratton, “Deeper tissue imaging with total detection,” Science 331, 1016–1017 (2011).
W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science, 248, 73–76 (1990).
C. A. Combs, A. Smirnov, D. Chess, D. B. Mcgavern, J. L. Schroeder, J. Riley, S. S. Kang, M. Lugar-Hammer, A. Gandjbakhche, J. R. Knutson, and R. S. Balaban, “Optimizing multiphoton fluorescence microscopy light collection from living tissue by noncontact total emission detection (epiTED),” J. Microsc. 241(2), 153–161 (2011).
C. A. Combs, A. V. Smirnov, J. D. Riley, A. H. Gandjbakhche, J. R. Knutson, and R. S. Balaban, “Optimization of multiphoton excitation microscopy by total emission detection using a parabolic light reflector,” J. Microsc. 228(3), 330–337 (2007).
R. K. Wang, and V. V. Tuchin, “Optical coherence tomography. Light scattering and imaging enhancement,” Chap. 16 in Handbook of Coherent-Domain Optical Methods. Biomedical Diagnostics, Environmental Monitoring, and Material Science, 2nd ed., V. V. Tuchin, Ed., pp. 665-742, New York, Heidelberg, Dordrecht, London: Springer (2013).
L. V. Wang, and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335, 1458–1462 (2012).
Y. M. Liew, R. A. McLaughlin, F. M. Wood, and D. D. Sampson, “Reduction of image artifacts in three-dimensional optical coherence tomography of skin in vivo,” J. Biomed. Opt. 16(11), 116018 (2011).
V. V. Tuchin, “A clear vision for laser diagnostics (Review),” IEEE J. Sel. Top. Quantum Electron. 13, 1621–1628 (2007).
V. V. Tuchin, Optical Clearing of Tissues and Blood, SPIE Press, Bellingham, WA, USA 2006.
R. Cicchi, F. S. Pavone, D. Massi, and D. D. Sampson, “Contrast and depth enhancement in two-photon microscopy of human skin ex vivo by use of optical clearing agents,” Opt. Exp. 13, 2337–2344 (2005).
S. Plotnikov, V. Juneja, A. B. Isaacson, W. A. Mohler, and P. J. Campagnola, “Optical clearing for improved contrast in second harmonic generation imaging of skeletal muscle,” Biophys. J. 90, 328–339 (2006).
E. A. Genina, A. N. Bashkatov, Yu. P. Sinichkin, and V. V. Tuchin, “Optical clearing of the eye sclera in vivo caused by glucose,” Quantum Electronics 36(12), 1119-1124 (2006).
G. Vargas, J. K. Barton, and A. J. Welch, “Use of hyperosmotic chemical agent to improve the laser treatment of cutaneous vascular lesions,” J. Biomed. Opt. 13(2), 021114 (2008).
M. H. Khan, S. Chess, B. Choi, K. M. Kelly, and J. S. Nelson, “Can topically applied optical clearing agents increase the epidermal damage threshold and enhance therapeutic efficacy?,” Lasers Surg. Med. 35, 93–95 (2004).
P. D. Agrba, M. Yu. Kirillin, A. I. Abelevich, E. V. Zagaynova, and V. A. Kamensky, “Compression as a method for increasing the informativity of optical coherence tomography of biotissue,” Optics and Spectroscopy 107(6), 853-858 (2009).
C. Drew, T. E. Milner, and C. G. Rylander, “Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using optical coherence tomography,” J. Biomed. Opt. 14(6), 064019 (2009).
N. Guzelsu, J. F. Federici, H. C. Lim, H. R. Chauhdry, A. B. Ritter, and T. Findley, “Measurement of skin strech via light reflection,” J. Biomed. Opt. 8, 80–86 (2003).
C. G. Rylander, O. F. Stumpp, T. E. Milner, N. J. Kemp, J. M. Mendenhall, K. R. Diller, and A. J. Welch, “Dehydration mechanism of optical clearing in tissue,” J. Biomed. Opt. 11, 041117 (2006).
T. Yu, X. Wen, V. V. Tuchin, Q. Luo, and D. Zhu, “Quantitative analysis of dehydration in porcine skin for assessing mechanism of optical clearing,” J. Biomed. Opt. 16, 095002 (2011).
W.-C. Lin, M. Motamedi, and A. J. Welch, “Dynamics of tissue optics during laser heating of turbid media,” Appl. Opt. 35(19), 3413–3420 (1996).
D. Zhu, J. Wang, Z. Zhi, X. Wen, and Q. Luo, “Imaging dermal blood flow through the intact rat skin with an optical clearing method,” J. Biomed. Opt. 15, 026008 (2010).
K. V. Larin, M. G. Ghosn, A. N. Bashkatov, E. A. Genina, N. A. Trunina, and V. V. Tuchin, “Optical clearing for OCT image enhancement and in-depth monitoring of molecular diffusion,” IEEE J. Select. Tops. Quantum Electron. 18, 1244–1259 (2012).
D. Zhu, K. Larin, Q. Luo, and V. V. Tuchin, “Recent progress in tissue optical clearing,” Laser & Photonics Reviews 7(5), 732-757 (2013).
V. A. Doubrovskii, I. Yu. Yanina, and V. V. Tuchin, “Kinetics of changes in the coefficient of transmission of the adipose tissue in vitro as a result of photodynamic action,” Biophysics 57(1), 94-98 (2012).
I. Yu. Yanina, N. A. Trunina, and V. V. Tuchin, “Optical coherence tomography of adipose tissue at photodynamic/photothermal treatment in vitro,” Journal of Innovative Optical Health Sciences 6(2), 1350010 (2013).
E. A. Genina, A. N. Bashkatov, and V. V. Tuchin, “Tissue optical immersion clearing,” Expert Rev. Med. Devices 7, 825–842 (2010).
R. Barer, “Spectrophotometry of clarified cell suspensions,” Science 121, 709–715 (1955).
V. V. Bakutkin, and L. P. Shubochkin, “The increase in light transmission of the sclera and the diseased cornea,” Ophthalmological Journal 2, 105-107 (1991) (in Russian).
V. V. Tuchin, I. L. Maksimova, D. A. Zimnyakov, I. L. Kon, A. H. Mavlutov, and A. A. Mishin, “Light propagation in tissues with controlled optical properties,” Proc. SPIE 2925, 118-142 (1996).
V. V. Tuchin, I. L. Maksimova, D. A. Zimnyakov, I. L. Kon, A. H. Mavlutov, and A. A. Mishin, “Light propagation in tissues with controlled optical properties,” J. Biomed. Opt. 2, 401–417 (1997).
A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Tuchin, and Y. P. Sinichkin, “The influence of osmotically active chemical agents on the transport of light in the scleral tissue,” Proc. SPIE 3726, 403-409 (1998).
V. V. Tuchin, A. N. Bashkatov, E. A. Genina, Yu. P. Sinichkin, and N. A. Lakodina, “In vivo investigation of the immersion-liquid-induced human skin clearing dynamics,” Technical Physics Letters 27(6), 489-490 (2001).
E. A. Genina, Investigation of optical immersion and staining of biological tissues in vivo for optical diagnostics and laser therapy, Ph.D. thesis, Saratov State University, Saratov, Russia (2002) (in Russia).
A. N. Bashkatov, Control of tissue optical properties by means of osmotically active immersion liquids, Ph. D. thesis, Saratov State University, Saratov, Russia (2002) (in Russia).
I. V. Meglinskii, A. N. Bashkatov, E. A. Genina, D. Yu. Churmakov, and V. V. Tuchin, “Study of the possibility of increasing the probing depth by the method of reflection confocal microscopy upon immersion clearing of near-surface human skin layers,” Quantum Electronics 32(10), 875-882 (2002).
I. V. Meglinski, A. N. Bashkatov, E. A. Genina, D. Y. Churmakov, and V. V. Tuchin, “The enhancement of confocal images of tissues at bulk optical immersion,” Laser Physics 13(1), 65–69 (2003).
E. I. Galanzha, V. V. Tuchin, A. V. Solovieva, T. V. Stepanova, Q. Luo, and H. Cheng, J., “Skin backreflectance and microvascular system functioning at the action of osmotic agents,” Phys. D: Appl. Phys. 36, 1739–1746 (2003).
V. V. Tuchin, D. M. Zhestkov, A. N. Bashkatov, and E. A. Genina, “Theoretical study of immersion optical clearing of blood in vessels at local hemolysis,” Optics Express 12(13), 2966-2971 (2004).
E. A. Genina, A. N. Bashkatov, V. I. Kochubey, and V. V. Tuchin, “Optical clearing of human dura mater,” Optics and Spectroscopy 98(3), 470-476 (2005).
A. N. Bashkatov, D. M. Zhestkov, E. A. Genina, and V. V. Tuchin, “Immersion clearing of human blood in the visible and near-infrared spectral regions,” Optics and Spectroscopy 98(4), 638-646 (2005).
V. V. Tuchin, “Optical clearing of tissues and blood using the immersion method,” J. Phys. D: Appl. Phys. 38, 2497–2518 (2005).
V. V. Tuchin, “Optical immersion as a new tool for controlling the optical properties of tissues and blood,” Laser Phys. 15, 1109–1136 (2005).
E. A. Genina, A. N. Bashkatov, A. A. Korobko, E. A. Zubkova, V. V. Tuchin, I. V. Yaroslavsky, and G. B. Altshuler, “Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin,” J. Biomed. Opt. 13, 021102 (2008).
E. A. Genina, A. N. Bashkatov, and V. V. Tuchin. “Optical clearing of cranial bone,” Advanced Optical Technologies 267867 (2008).
E. A. Genina, A. N. Bashkatov, K. V. Larin, and V. V. Tuchin, “Light-tissue interaction at optical clearing,” Laser Imaging and Manipulation in Cell Biology, 115-164, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim (2010).
I. V. Larina, E. F. Carbajal, V. V. Tuchin, M. E. Dickinson, and K. V. Larin, “Enhanced OCT imaging of embryonic tissue with optical clearing,” Laser Phys. Lett. 5, 476–479 (2008).
S. G. Proskurin, and I. V. Meglinski, “Optical coherence tomography imaging depth enhancement by superficial skin optical clearing,” Laser Phys. Lett. 4, 824–826 (2007).
M. Bonesi, S. G. Proskurin, and I. V. Meglinski, “Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography,” Laser Phys. 20, 891–899 (2010).
G. Vargas, E. K. Chan, J. K. Barton, H. G. Rylander, and A. J. Welch, “Use of an agent to reduce scattering in skin,” Lasers Surg. Med. 24(2), 133–141 (1999).
G. Vargas, “Reduction of light scattering in biological tissue: implications for optical diagnostics and therapeutics,” PhD Thesis, The University of Texas, USA (2001).
G. Vargas, K. F. Chan, S. L. Thomsen, and A. J. Welch, “Use of osmotically active agents to alter optical properties of tissue: effects on the detected fluorescence signal measured through skin,” Lasers Surg. Med. 29(3), 213-220 (2001).
G. Vargas, A. Readinger, S. S. Dosier, and A. J. Welch, “Morphological changes in blood vessels produced by hyperosmotic agents and measured by optical coherence tomography,” Photochem. Photobiol. 77, 541–549 (2003).
R. K. Wang, X. Xu, V. V. Tuchin, and J. B. Elder, “Concurrent enhancement of imaging depth and contrast for optical coherence tomography by hyperosmotic agents,” J. Opt. Soc. Am. B 18, 948–953 (2001).
X. Xu, and R. K. Wang, “The role of water desorption on optical clearing of biotissue: studied with near infrared reflectance spectroscopy,” Med. Phys. 30, 1246–1253 (2003).
Y. He, R. K. Wang, and D. Xing, “Enhanced sensitivity and spatial resolution for in vivo imaging with low-level light-emitting probes by use of biocompatible chemical agents,” Opt. Lett. 28, 2076–2078 (2003).
Y. He, and R. K. Wang, “Dynamic optical clearing effect of tissue impregnated with hyperosmotic agents and studied with optical coherence tomography,” J. Biomed. Opt. 9, 200–206 (2004).
M. H. Khan, B. Choi, S. Chess, K. M. Kelly, J. McCullough, and J. S. Nelson, “Optical clearing of in vivo human skin: implications for light-based diagnostic imaging and therapeutics,” Lasers Surg. Med. 34, 83–85 (2004).
H. Cheng, Q. Luo, S. Zeng, S. Chen,W. Luo, and H. Gong, “Hyperosmotic chemical agent's effect on in vivo cerebral blood flow revealed by laser speckle,” Appl. Opt. 43, 5772–5777 (2004).
R. LaComb, O. Nadiarnykh, S. Carey, and P. J. Campagnola, “Quantitative second harmonic generation imaging and modeling of the optical clearing mechanism in striated muscle and tendon,” J. Biomed. Opt. 13, 021109 (2008).
O. Nadiarnykh, and P. J. Campagnola, “Retention of polarization signatures in SHG microscopy of scattering tissues through optical clearing,” Opt. Exp. 17, 5794–5806 (2009).
D. Zhu, Q. Luo, and J. Cen, “Effects of dehydration on the optical properties of in vitro porcine liver,” Lasers Surg. Med. 33, 226-231 (2003).
D. Zhu, J. Zhang, H. Cui, Z. Mao, P. Li, and Q. Luo, “Short-term and long-term effects of optical clearing agents on blood vessels in chick chorioallantoic membrane,” J. Biomed. Opt. 13(2), 021106 (2008).
X. Wen, Z. Mao, Z. Han, V. V. Tuchin, and D. Zhu, “In vivo skin optical clearing by glycerol solutions: mechanism,” J. Biophotonics 3(1-2), 44-52 (2010).
J. Wang, D. Zhu, M. Chen, and X. Liu, “Assessment of optical clearing induced improvement of laser speckle contrast imaging,” J. Innovat. Opt. Health Sci. 3, 159–167 (2010).
T. Yu, X. Wen, V. V. Tuchin, Q. Luo, and D. Zhu, “Quantitative analysis of dehydration in porcine skin for assessing mechanism of optical clearing,” J. Biomed. Opt. 16(9), 095002 (2011).
J. Wang, Y. Zhang, T. Xu, Q. Luo, and D. Zhu, “An innovative transparent cranial window based on skull optical clearing,” Laser Phys. Lett. 9, 469–473 (2012).
X. Wen, S. L. Jacques, V. V. Tuchin, and D. Zhu, “Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging,” J. Biomed. Opt. 17, 066022 (2012).
J. Wang, Y. Zhang, P. Li, Q. Luo, and D. Zhu, “Review: tissue optical clearing window for blood flow monitoring,” IEEE J. Sel. Topics in Quantum Electron. 20(2), 6801112 (2014).
M. Kinnunen, R. Myllylä, and S. Vainio, “Detecting glucose-induced changes in in vitro and in vivo experiments with optical coherence tomography,” J. Biomed. Opt. 13, 021111 (2008).
R. Dickie, R. M. Bachoo, M. A. Rupnick, S. M. Dallabrida, G. M. DeLoid, J. Lai, R. A. DePinho, and R. A. Rogers, “Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy,” Microvasc. Res. 72, 20–26 (2006).
V. Hovhannisyan, P.-S. Hu, S.-J. Chen, C.-S. Kim, and C.-Y. Dong, “Elucidation of the mechanisms of optical clearing in collagen tissue with multiphoton imaging,” J. Biomed. Opt. 18(4), 046004 (2013).
H. Hama, H. Kurokawa, H. Kawano, R. Ando, T. Shimogori, H. Noda, K. Fukami, A. Sakaue-Sawano, and A. Miyawaki, “Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain,” Nature Neurosci. 14, 1481–1488 (2011).
H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgnsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nature Methods 4(4), 331–336 (2007).
A. Ertürk, C. P. Mauch, F. Hellal, F. Förstner, T. Keck, K. Becker, N. Jährling, H. Steffens, M. Richter, M. Hübener, E. Kramer, F. Kirchhoff, H. U. Dodt, and F. Bradke, “Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury,” Nature Med. 18, 166–171 (2012).
A. N. Bashkatov, E. A. Genina, Yu. P. Sinichkin, V. I. Kochubey, N. A. Lakodina, and V. V. Tuchin, “Glucose and mannitol diffusion in human dura mater,” Biophys. J. 85(5), 3310-3318 (2003).
M. G. Ghosn, V. V. Tuchin, and K. V. Larin, “Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography,” Opt. Lett. 31, 2314–2316 (2006).
A. N. Bashkatov, E. A. Genina, and V. V. Tuchin, “Measurement of glucose diffusion coefficients in human tissues,” Chap. 19 in Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues, V. V. Tuchin, Ed., pp. 587-621, Taylor & Francis Group LLC, CRC Press (2009).
A. N. Bashkatov, E. A. Genina, Yu. P. Sinichkin, V. I. Kochubei, N. A. Lakodina, and V. V. Tuchin, “Estimation of the glucose diffusion coefficient in human eye sclera,” Biophysics 48(2), 292-296 (2003).
E. A. Genina, A. N. Bashkatov, E. A. Zubkova, T. G. Kamenskikh, and V. V. Tuchin, “Measurements of Retinalamin diffusion coefficient in human sclera by optical spectroscopy,” Optics and Lasers in Engineering 46, 915-920 (2008).
E. A. Genina, A. N. Bashkatov, V. V. Tuchin, M. G. Ghosn, K. V. Larin, and T. G. Kamenskikh, “Cortexin diffusion in human eye sclera,” Quantum Electronics 41(5), 407-413 (2011).
E. A. Zubkina, E. A. Genina, A. N. Bashkatov, and V. V. Tuchin, “Optical clearing of eye tissues,” Proceedings of the Samara Scientific Center of the Russian Academy of Sciences 13(4(2)), 588-594 (2011) (in Russia).
M. G. Ghosn, V. V. Tuchin, and K. V. Larin, “Nondestructive quantification of analyte diffusion in cornea and sclera using optical coherence tomography,” Invest. Ophthal. Visual Sci. 48, 2726–2733 (2007).
M. G. Ghosn, E. F. Carbajal, N. Befrui, V. V. Tuchin, and K. V. Larin, “Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera,” J. Biomed. Opt. 13, 021110 (2008).
M. G. Ghosn, N. Sudheendran, M. Wendt, A. Glasser, V. V. Tuchin, and K. V. Larin, “Monitoring of glucose permeability in monkey skin in vivo using optical coherence tomography,” J. Biophotonics 3, 25–33 (2010).
X. Guo, Z. Guo, H. Wei, H. Yang, Y. He, S. Xie, G. Wu, X. Deng, Q. Zhao, and L. Li, “In vivo comparison of the optical clearing efficacy of optical clearing agents in human skin by quantifying permeability using optical coherence tomography,” Photochem. Photobiol. 87, 734–740 (2011).
K. V. Larin, M. G. Ghosn, S. N. Ivers, A. Tellez, and J. F. Granada, “Quantification of glucose diffusion in arterial tissues by using optical coherence tomography,” Laser Physics Letters 4(4), 312-317 (2007).
X. Guo, G. Wu, H. Wei, X. Deng, H. Yang, Y. Ji, Y. He, Z. Guo, S. Xie, H. Zhong, Q. Zhao, and Z. Zhu, “Quantification of glucose diffusion in human lung tissues by using Fourier domain optical coherence tomography,” Photochem. Photobiol. 88, 311–316 (2012).
S. Tanev, V. V. Tuchin, and P. Paddon, “Cell membrane and gold nanoparticles effects on optical immersion experiments with noncancerous and cancerous cells: finite-difference time-domain modeling,” J. Biomed. Opt. 11, 064037 (2006).
M. G. Ghosn, E. F. Carbajal, N. A. Befrui, A. Tellez, J. F. Granada, and K. V. Larin, “Permeability of hyperosmotic agent in normal and atherosclerotic vascular tissues,” J. Biomed. Opt. 13, 010505 (2008).
H. Q. Zhong, Z. Y. Guo, H. J. Wei, C. C. Zeng, H. L. Xiong, Y. H. He, and S. H. Liu, “Quantification of glycerol diffusion in human normal and cancer breast tissues in vitro with optical coherence tomography,” Laser Phys. Lett. 7, 315–320 (2010).
Q. L. Zhao, J. L. Si, Z. Y. Guo, H. J. Wei, H. Q. Yang, G. Y. Wu, S. S. Xie, X. Y. Li, X. Guo, H. Q. Zhong, and L. Q. Li, “Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography,” Laser Phys. Lett. 8, 71–77 (2011).
Z. Zhu, G. Wu, H. Wei, H. Yang, Y. He, S. Xie, Q. Zhao, and X. Guo, “Investigation of the permeability and optical clearing ability of different analytes in human normal and cancerous breast tissues by spectral domain OCT,” J. Biophoton. 5, 1–8 (2012).
B. Choi, L. Tsu, E. Chen, T. S. Ishak, S. M. Iskandar, S. Chess, and J. S. Nelson, “Determination of chemical agent optical clearing potential using in vitro human skin,” Lasers Surg. Med. 36, 72–75 (2005).
Z. Mao, D. Zhu, Y. Hu, X. Wen, and Z. Han, “Influence of alcohols on the optical clearing effect of skin in vitro,” J. Biomed. Opt. 13, 021104 (2008).
E. A. Genina, A. N. Bashkatov, Yu. P. Sinichkin, and V. V. Tuchin, “Optical clearing of skin under action of glycerol: ex vivo and in vivo investigations,” Optics and Spectroscopy 109(2), 225-231 (2010).
J. Hirshburg, B. Choi, J. S. Nelson, and A. T. Yeh, “Correlation between collagen solubility and skin optical clearing using sugars,” Lasers Surg. Med. 39, 140-144 (2007).
J. M. Hirshburg, K. M. Ravikumar, W. Hwang, and A. T. Yeh, “Molecular basis for optical clearing of collagenous tissues,” J. Biomed. Opt. 15(5), 055002 (2010).
J. Wang, N. Ma, R. Shi, Y. Zhang, T. Yu, and D. Zhu, “Sugar-induced skin optical clearing: from molecular dynamics simulation to experimental demonstration,” IEEE J. Selected Topics in Quantum Electronics 20(2), 7101007 (2014).
A. T. Yeh, and J. Hirshburg, “Molecular interactions of exogenous chemical agents with collagen-implications for tissue optical clearing,” J. Biomed. Opt. 11(1), 014003 (2006).
Y. Ding, J. Wang, Z. Fan, D. Wei, R. Shi, Q. Luo, D. Zhu, and X. Wei, “Signal and depth enhancement for in vivo flow cytometer measurement of ear skin by optical clearing agents,” Biomed. Opt. Exp. 4(11), 2518-2526 (2013).
J. Jiang, and R. K. Wang, “Comparing the synergistic effects of oleic acid and dimethyl sulfoxide as vehicles for optical clearing of skin tissue in vitro,” Phys. Med. Biol. 49, 5283–5294 (2004).
Y. Liu, X. Yang, D. Zhu, and Q. Luo, “Optical clearing agents improve photoacoustic imaging in the optical diffusive regime,” Optics Letters 38(20), 4236-4239 (2013).
X. Xu, and R. K. Wang, “Synergistic effect of hyperosmotic agents of dimethyl sulfoxide and glycerol on optical clearing of gastric tissue studied with near infrared spectroscopy,” Phys. Med. Biol. 49, 457–468 (2004).
J. Jiang, M. Boese, P. Turner, and R. K. Wang, “Penetration kinetics of dimethyl sulphoxide and glycerol in dynamic optical clearing of porcine skin tissue in vitro studied by Fourier transform infrared spectroscopic imaging,” J. Biomed. Opt. 13(2), 021105 (2008).
E. A. Genina, A. N. Bashkatov, E. A. Kolesnikova, M. V. Basco, G. S. Terentyuk, and V. V. Tuchin, “Optical coherence tomography monitoring of enhanced skin optical clearing in rats in vivo,” J. Biomed. Opt. 19(2), 021109 (2014).
A. N. Bashkatov, A. N. Korolevich, V. V. Tuchin, Y. P. Sinichkin, E. A. Genina, M. M. Stolnitz, N. S. Dubina, S. I. Vecherinski, and M. S. Belsley, “In vivo investigation of human skin optical clearing and blood microcirculation under the action of glucose solution,” Asian J. Physics 15(1), 1–14 (2006).
E. A. Genina, A. N. Bashkatov, and V. V. Tuchin, “Glucose-induced optical clearing effects in tissues and blood,” Chap. 21 in Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues, V. V. Tuchin, Ed., pp. 657-692, Taylor & Francis Group LLC, CRC Press (2009).
A. T. Yeh, B. Choi, J. S. Nelson, and B. J. Tromberg, “Reversible dissociation of collagen in tissues,” J. Invest. Dermatol. 121, 1332–1335 (2003).
J. Hirshburg, B. Choi, J. S. Nelson, and A. T. Yeh, “Collagen solubility correlates with skin optical clearing,” J. Biomed. Opt. 11, 040501 (2006).
J. W. Wiechers, J. C. Dederen, and A. V. Rawlings, “Moisturization mechanisms: internal occlusion by orthorhombic lipid phase stabilizers a novel mechanism of action of skin moisturization,” Chap. 9 in Skin Moisturization, 2nd ed., A. V. Rawlings and J. J. Leyden, Eds., pp. 309–321, Informa Healthcare, Taylor & Francis Group, New York (2009).
A. V. Papaev, G. V. Simonenko, V. V. Tuchin, and T. P. Denisova, “Optical anisotropy of a biological tissue under conditions of immersion clearing and without them,” Optics and Spectroscopy 101(1), 46-53 (2006).
A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Mueller, “Optical properties of circulating human blood in the wavelength range 400–2500 nm,” J. Biomed. Opt. 4, 36–46 (1999).
M. Friebel, J. Helfmann, and M. Meinke, “Influence of osmolarity on the optical properties of human erythrocytes,” J. Biomed. Opt. 15(5), 055005 (2010).
I. Fine, B. Fikhte, and L. D. Shvartsman, ”RBC aggregation assisted light transmission through blood and occlusion oximetry,” Proc. SPIE 4162, 130–139 (2000).
V. V. Tuchin, X. Xu, and R. K. Wang, “Dynamic optical coherence tomography in studies of optical clearing, sedimentation, and aggregation of immersed blood,” Appl. Opt. 41(1), 258–271 (2002).
H. Schaefer, and T. E. Redelmeier, Skin Barrier, Karger, Basel (1996).
C. Liu, Z. Zhi, V. V. Tuchin, Q. Luo, and D. Zhu, “Enhancement of skin optical clearing efficacy using photo-irradiation,” Lasers Surg. Med. 42, 132–140 (2010).
V. V. Tuchin, G. B. Altshuler, A. A. Gavrilova, A. B. Pravdin, D. Tabatadze, J. Childs, and I. V. Yaroslavsky, “Optical clearing of skin using flashlamp-induced enhancement of epidermal permeability,” Lasers Surg. Med. 38, 824–836 (2006).
E. A. Kolesnikova, A. S. Kolesnikov, E. A. Genina, L. E. Dolotov, D. K. Tuchina, A. N. Bashkatov, and V. V. Tuchin, “Use of fractional laser microablation of skin for improvement of its immersion clearing,” Proc. SPIE 8699, 86990B (2013).
E. A. Genina, A. N. Bashkatov, V. V. Tuchin, G. B. Altshuler, and I. V. Yaroslavski, “Possibility of increasing the efficiency of laser-induced tattoo removal by optical skin clearing,” Quantum Electronics 38(6), 580-587 (2008).
X. Xu, Q. Zhu, and C. Sun, “Assessment of the effects of ultrasound-mediated alcohols on skin optical clearing,” J. Biomed. Opt. 14, 034042 (2009).
H. Zhong, Z. Guo, H. Wei, C. Zeng, H. Xiong, Y. He, and S. Liu, “In vitro study of ultrasound and different-concentration glycerol-induced changes in human skin optical attenuation assessed with optical coherence tomography,” J. Biomed. Opt. 15, 036012 (2010).
O. Stumpp, B. Chen, and B. Welch, “Using sandpaper for noninvasive transepidermal optical skin clearing agent delivery,” J. Biomed. Opt. 11, 041118 (2006).
J. Yoon, T. Son, E. Choi, B. Choi, J. S. Nelson, and B. Jung, “Enhancement of optical clearing efficacy using a microneedle roller,” J. Biomed. Opt. 13(2), 021103 (2008).
J. Yoon, D. Park, T. Son, J. Seo, J. S. Nelson, and B. Jung, “A physical method to enhance transdermal delivery of a tissue optical clearing agent: combination of microneedling and sonophoresis,” Lasers Surg. Med. 42, 412-417 (2010).
M. A. Fox, D. G. Diven, K. Sra, A. Boretsky, T. Poonawalla, A. Readinger, M. Motamedi, and R. J. Nichols, “Dermal scatter reduction in human skin: a method using controlled application of glycerol,” Lasers Surg. Med. 41, 251-255 (2009).
C. G. Rylander, T. E. Milner, S. A. Baranov, and J. S. Nelson, “Mechanical tissue optical clearing devices: enhancement of light penetration in ex vivo porcine skin and adipose tissue,” Lasers Surg. Med. 40, 688-694 (2008).
X. Xu, and Q. Zhu, “Evaluation of skin optical clearing enhancement with Azone as a penetration enhancer,” Optics Communications 279, 223-228 (2007).
J. Jiang, and R. K. Wang, “How different molarities of oleic acid as enhancer exert its effect on optical clearing of skin tissue in vitro,” Journal of X-Ray Science and Technology, 13, 149-159 (2005).
J. Jiang, M. Boese, P. Turner, and R. K. Wang, “Penetration kinetics of dimethyl sulphoxide and glycerol in dynamic optical clearing of porcine skin tissue in vitro studied by Fourier transform infrared spectroscopic imaging,” J. Biomed. Opt. 13(2), 021105 (2008).
A. K. Bui, R. A. McClure, J. Chang, C. Stoianovici, J. Hirshburg, A. T. Yeh, and B. Choi, “Revisiting optical clearing with dimethyl sulfoxide (DMSO),” Lasers Surg. Med. 41, 142-148 (2009).
M. Zimmerley, R. A. McClure, B. Choi, and E. O. Potma, “Following dimethyl sulfoxide skin optical clearing dynamics with quantitative nonlinear multimodal microscopy,” Appl. Opt. 48(10), D79-D87 (2009).
S. Karma, J. Homan, C. Stoianovic, and B. Choi, “Enhanced fluorescence imaging with DMSO-mediated optical clearing,” Journal of Innovative Optical Health Sciences 3(3), 153-158 (2010).
Z. Zhi, Z. Han, Q. Luo, and D. Zhu, “Improve optical clearing of skin in vitro with propylene glycol as a penetration enhancer,” Journal of Innovative Optical Health Sciences 2(3), 269-278 (2009).
X. Xu, Q. Zhu, and C. Sun, “Combined effect of ultrasound-SLS on skin optical clearing,” IEEE Photonic Technol. Lett. 20(24), 2117–2119 (2008).
H. Zhong, Z. Guo, H. Wei, L. Guo, C. Wang, Y. He, H. Xiong, and S. Liu, “Synergistic effect of ultrasound and thiazone–PEG 400 on human skin optical clearing in vivo,” Photochem. Photobiol. 86(3), 732–737 (2010).
T. Kurihara-Bergstrom, K. Knutson, L. J. de Noble, and C. Y. Goates, “Percutaneous absorption enhancement of an ionic molecule by ethanol–water system in human skin,” Pharm. Res. 7, 762–766 (1990).
A. C. Williams, and B. W. Barry, “Penetration enhancers,” Adv. Drug Deliv. Rev. 56, 603–618 (2004).
J.-M. Andanson, K. L. A. Chan, and S. G. Kazarian, “High-throughput spectroscopic imaging applied to permeation through the skin,” Appl. Spectrosc. 63(5), 512–517 (2009).
A. P. Funke, R. Schiller, H. W. Motzkus, C. Gunther, R. H. Muller, and R. Lipp, “Transdermal delivery of highly lipophilic drugs: in vitro fluxes of antiestrogens, permeation enhancers, and solvents from liquid formulations,” Pharm. Res. 19(5), 661–668 (2002).
A. Pagnoni, A. Knuettel, P. Welker, M. Rist, T. Stoudemayer, L. Kolbe, I. Sadiq, and A. M. Kligman, “Optical coherence tomography in dermatology,” Skin Res. Technol. 5(2), 83–87 (1999).
R. Samatham, K. G. Phillips, and S. L. Jacques, “Assessment of optical clearing agents using reflectance-mode confocal scanning laser microscopy,” J. Innovative Opt. Health Sci. 3(3), 183–188 (2010).
P. Liu, Y. Huang, Z. Guo, J. Wang, Z. Zhuang, and S. Liu, “Discrimination of dimethyl sulphoxide diffusion coefficient in the process of optical clearing by confocal micro-Raman spectroscopy,” J. Biomed. Opt. 18(2), 020507 (2013).
G. Terentyuk, E. Panfilova, V. Khanadeev, D. Chumakov, E. Genina, A. Bashkatov, V. Tuchin, N. Khlebtsov, and B. Khlebtsov, “Gold nanorods with hematoporphyrin-loaded silica shell for dual-modality photodynamic and photothermal treatment of tumors in vivo,” NanoResearch 7(3), 325–337 (2014).
O. Stumpp, A. J. Welch, and J. Neev, “Enhancement of transdermal skin clearing agent delivery using a 980 nm diode laser,” Lasers Surg. Med. 37, 278–285 (2005).
A. Tezel, and S. Mitragotri, “Interaction of inertial cavitation bubbles with stratum corneum lipid bilayers during low frequency sonophoresis,” Biophys. J. 85, 3502–3512 (2003).
A. K. Nugroho, G. L. Li, M. Danhof, and J. A. Bouwstra, “Transdermal iontophoresis of rotigotine across human stratum corneum in vitro: influence of pH and NaCl concentration,” Pharm. Res. 21(5), 844–850 (2004).
O. Stumpp, and A. J. Welch, “Injection of glycerol into porcine skin for optical skin clearing with needle-free injection gun and determination of agent distribution using OCT and fluorescence microscopy,” Proc. SPIE 4949, 44–50 (2003).
H.-J. Weigmann, J. Lademann, S. Schanzer, U. Lindemann, R. von Pelchrzim, H. Schaefer, W. Sterry, and V. Shah, “Correlation of the local distribution of topically applied substances inside the stratum corneum determined by tape stripping to differences in bioavailability,” Skin Pharmacol. Appl. Skin Physiol. 14, 93–103 (2001).
W. R. Lee, R. Y. Tsai, C. L. Fang, C. J. Liu, C. H. Hu, and J. Y. Fang, “Microdermabrasion as a novel tool to enhance drug delivery via the skin: an animal study,” J. Dermatol. Surg. 32, 1013–1022 (2006).
A. N. Bashkatov, E. A. Genina, V. V. Tuchin, and G. B. Altshuler, “Skin optical clearing for improvement of laser tattoo removal,” Laser Physics 19(6), 1312-1322 (2009).
X. Xu, and Q. Zhu, “Feasibility of sonophoretic delivery for effective skin optical clearing,” IEEE Trans. Biomed. Eng. 55(4), 1432–1437 (2008).
X. Xu, and Q. Zhu, “Sonophoretic delivery for contrast and depth improvement in skin optical coherence tomography,” IEEE J. Sel. Top. Quantum Electron. 14(1), 56–61 (2008).
I. Lavon, N. Grossman, J. Kost, E. Kimmel, and G. Enden, “Bubble growth within the skin by rectified diffusion might play a significant role in sonophoresis,” J. Controlled Release 117(2), 246–255 (2007).
X. Xu, and C. Sun, “Ultrasound enhanced skin optical clearing: microstructural changes,” J. Innovative Opt. Health Sci. 3(3), 189–194 (2010).
A. K. Nugroho, O. Della Pasqua, M. Danhof, and J. A. Bouwstra, “Compartmental modeling of transdermal iontophoretic transport: I. in vitro model derivation and application,” Pharmaceutical Research 21(11), 1974-1984 (2004).
J. Wang, X. Zhou, S. Duan, Z. Chen, and D. Zhu, “Improvement of in vivo rat skin optical clearing with chemical penetration enhancers,” Proc. SPIE 7883, 78830Y (2011).
Yu. P. Sinichkin, and S. R. Utz, In vivo reflectance and fluorescence spectroscopy of human skin, Saratov: Saratov University Press (2001).
Yu. P. Sinichkin, N. Kollias, G. Zonios, S. R. Utz, and V. V. Tuchin, “Back reflectance and fluorescence spectroscopy of the human skin in vivo,” in Handbook on Optical Biomedical Diagnostics and Imaging, V. V. Tuchin, Ed., pp. 725-785, Bellingham, SPIE Press (2002).
G. A. Askar'yan, “Enhancement of transmission of laser and other radiation by soft turbid physical and biological media,” Sov. J. Quantum Electron. 12(7), 877-880 (1982).
E. K. Chan, B. Sorg, D. Protsenko, M. O’Neil, M. Motamedi, and A. J. Welch, “Effects of compression on soft tissue optical properties,” IEEE J. Sel. Topics in Quantum Electr. 2(4), 943–950 (1996).
H. Shangguan, S. A. Prahl, S. L. Jacques, and L. W. Casperson, “Pressure effects on soft tissues monitored by changes in tissue optical properties,” Proc. SPIE 3254, 366–371 (1998).
Yu. P. Sinichkin, S. R. Uts, and E. A. Pilipenko, “Spectroscopy of human skin in vivo: 1. Reflection spectra,” Optics and Spectroscopy 80(2). 228-234 (1996).
B. W. Murphy, R. J. Webster, B. A. Turlach, C. J. Quirk, C. D. Clay, P. J. Heenan, and D. D. Sampson, “Toward the discrimination of early melanoma from common and dysplastic nevus using fiber optic diffuse reflectance spectroscopy,” J Biomed. Opt. 10(6), 064020 (2005).
W. Chen, R. Liu, K. Xu, and R. K. Wang, “Influence of contact state on NIR diffuse reflectance spectroscopy in vivo,” J. Phys. D: Appl. Phys. 38, 2691-2695 (2005).
L. L. Randeberg, Diagnostic applications of diffuse reflectance spectroscopy, PhD thesis, Norwegian University of Science and Technology, Trondheim, Norway (2005).
S. A. Carp, T. Kauffman, Q. Fang, E. Rafferty, R. Moore, D. Kopans, and D. Boas, “Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements,” J. Biomed. Opt. 11(6), 064016 (2006).
R. Reif, M. S. Amorosino, K. W. Calabro, O. A’Amar, S. K. Singh, and I. J. Bigio, “Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures,” J. Biomed. Opt. 13(1), 010502 (2008).
Y. Ti, and W. C. Lin, “Effects of probe contact pressure on in vivo optical spectroscopy,” Opt. Express 16(6), 4250-4262 (2008).
A. Cerussi, S. Siavoshi, A. Durkin, C. Chen, W. Tanamai, D. Hsiang, and B. J. Tromberg, “Effect of contact force on breast tissue optical property measurements using a broadband diffuse optical spectroscopy handheld probe,” Appl. Opt. 48, 4270-4277 (2009).
J. A. Delgado Atencio, E. E. Orozco Guillén, S. Vázquezy Montiel, M. Cunill Rodríguez, J. Castro Ramos, J. L. Gutiérrez, and F. Martínez, “Influence of probe pressure on human skin diffuse reflectance spectroscopy measurements,” Optical Memory & Neural Networks (Information Optics) 18(1), 6-14 (2009).
L. Lim, B. Nichols, N. Rajaram, and J. W. Tunnell, “Probe pressure effects on human skin diffuse reflectance and fluorescence spectroscopy measurements,” J. Biomed. Opt. 16(1), 011012 (2011).
S. Ruderman, A. J. Gomes, V. Stoyneva, J. D. Rogers, A. J. Fought, B. D. Jovanovic, and V. Backman, “Analysis of pressure, angle and temporal effects on tissue optical properties from polarization-gated spectroscopic probe measurements,” Biomedical Optics Express 1(2), 489-499 (2010).
Yu. P. Sinichkin, S. R. Uts, I. V. Meglinskii, and E. A. Pilipenko, “Spectroscopy of human skin in vivo: II. Fluorescence spectra,” Optics and Spectroscopy 80(3). C. 383-389 (1996).
A. Nath, K. Rivoire, S. Chang, D. Cox, E. N. Atkinson, M. Follen, and R. Richards-Kortum, “Effect of probe pressure on cervical fluorescence spectroscopy measurements,” J. Biomed. Opt. 9(3), 523-533 (2004).
K. Rivoire, A. Nath, D. Cox, E. N. Atkinson, R. Richards-Kortum, and M. Follen, “The effects of repeated spectroscopic pressure measurements on fluorescence intensity in the cervix,” Am. J. Obstet. Gynecol. 191(5), 1606-1617 (2004).
A. Izquierdo-Roman, W. C. Vogt, L. Hyacinth, and C. G. Rylander, “Mechanical tissue optical clearing technique increases imaging resolution and contrast through ex vivo porcine skin,” Lasers Surg. Med. 43, 814–823 (2011).
V. V. Sapozhnikova, R. V. Kuranov, I. Cicenaite, R. O. Esenaliev, and D. S. Prough, “Effect on blood glucose monitoring of skin pressure exerted by an optical coherence tomography probe,” J. Biomed. Opt. 13(2), 021112 (2008).
M. Y. Kirillin, P. D. Agrba, and V. A. Kamensky, ”In vivo study of the effect of mechanical compression on formation of OCT images of human skin,” J. Biophotonics 3(12), 752–758 (2010).
A. A. Gurjarpadhye, W. C. Vogt, Y. Liu, and C. G. Rylander, “Effect of localized mechanical indentation on skin water content evaluated using OCT,” Int. J. Biomed. Imag. 2011, 817250 (2011).
M. H. Khan, B. Choi, S. Chess, K. M. Kelly, J. McCullought, and J. S. Nelson, “Optical clearing of in vivo human skin: Implications for light-based diagnostic imaging and therapeutics,” Lasers Surg. Med. 34(2), 83-85 (2004).
H. Kang, T. Son, J. Yoon, K. Kwon, J. S. Nelson, and B. Jung, “Evaluation of laser beam profile in soft tissue due to compression, glycerol, and micro-needling,” Laser Surg. Med. 40(8), 570-575 (2008).
C. G. Rylander, T. E. Milner, S. A. Baranov, and J. S. Nelson, “Mechanical tissue optical clearing devices: enhancement of light penetration in ex vivo porcine skin and adipose tissue,” Lasers Surg. Med. 40(10), 688-694 (2008).
I. V. Ermakov, and W. Gellermann, “Dermal carotenoid measurements via pressure mediated reflection spectroscopy,” J. Biophotonics 5(7), 559-570 (2012).
L. E. Dolotov, and Yu. P. Sinichkin, “Features of applying fiber-optic sensors in spectral measurements of biological tissues,” Optics and Spectroscopy 115(2), 187-192 (2013).
C. Li, J. Jiang, and K. Xu, “The variations of water in human tissue under certain compression: studied with diffuse reflectance spectroscopy,” J. Innov. Opt. Health Sci. 6(1), 1350005 (2013).
K. A. Martin, Direct measurement of moisture in skin by NIR spectroscopy,” J. Soc. Cosm. Chem. 44, 249-261 (1993).
C. W. J. Oomens, D. H. Vancampen, and H. J. Grootenboer, “A mixture approach to the mechanics of skin,” J. Biomech. 20(9), 877-885 (1987).
A. Hidenobu, and E. Mariko, “Non-contact skin moisture measurement based on near-infrared spectroscopy,” Appl. Spectrosc. 58, 1439-1446 (2004).
A. N. Bashkatov, E. A. Genina, and V. V. Tuchin, “Optical properties of skin, subcutaneous and muscle tissues, a review,” J. Innovative Opt. Health Sci. 14(1), 9-38 (2011).
T. L. Troy, and S. N. Thennadil, “Optical properties of human skin in the NIR wavelength range of 1000-2200 nm,” J. Biomed. Opt. 6, 167-176 (2001).
I. Yu. Yanina, G. V. Simonenko, and V. V. Tuchin, “Destructive fat tissue engineering using photodynamic and selective photothermal effects,” Proc SPIE 7179, 71790C (2009).
V. A. Doubrovsky, I. Yu. Yanina, and V. V. Tuchin, “Inhomogeneity of photo-induced fat cell lipolysis,” Proc. SPIE 7999, 79990M (2011).
Yu. A. Vladimirov, and A. Ya. Potapenko, Physico-chemical basis of photobiological processes, Moscow: Dropha (2006).
M. Wanner, M. Avram, D. Gagnon, M. C. Mihm Jr., D. Zurakowski, K. Watanabe, Z. Tannous, R. R. Anderson, and D. Manstein, “Effects of noninvasive, 1210 nm laser exposure on adipose tissue: results of a human pilot study,” Lasers Surg. Med. 41, 401–407 (2009).
W. R. Chen, R. L. Adams, S. Heaton, D. T. Dickey, K. E. Bartels, and R. E. Nordquist, “Chromophore-enhanced laser-tumor tissue photothermal interaction using an 808-nm diode laser,” Cancer Lett. 88, 15-19 (1995).
W. R. Chen, R. L. Adams, A. K. Higgins, K. E. Bartels, and R. E. Nordquist, “Photothermal effects on murine mammary tumors using indocyanine green and an 808-nm diode laser: an in vivo efficacy,” Cancer Lett. 98, 169-173 (1996).
S. Fickweiler, R. M. Szeimies, W. Baumler, P. Steinbach, S. Karrer, A. E. Goetz, C. Abels, F. Hofstadter, and M. Landthaler, “Indocyanine green: intracellular uptake and phototherapeutic effects in vitro,” J. Photochem. Photobiol. B 38, 178-183 (1997).
V. V. Tuchin, E. A. Genina, A. N. Bashkatov, G. V. Simonenko, O. D. Odoevskaya, and G. B. Altshuler, “A pilot study of ICG laser therapy of acne vulgaris: photodynamic and photothermolysis treatment,” Lasers Surg. Med. 33(5), 296-310 (2003).
E. A. Genina, A. N. Bashkatov, G. V. Simonenko, O. D. Odoevskaya, V. V. Tuchin, and G. B. Altshuler, “Low-intensity Indocyanine green - laser phototherapy of acne vulgaris: Pilot study,” J. Biomed. Opt. 9(4), 828-834 (2004).
V. I. Kochubey, T. V. Kulyabina, V. V. Tuchin, and G. B. Altshuler, “Spectral characteristics of indocyanine green upon its interaction with biological tissues,” Optics and Spectroscopy 99(4), 560-566 (2005).
E. A. Genina, A. N. Bashkatov, Yu. P. Sinichkin, V. I. Kochubey, N. A. Lakodina, G. B. Altshuler, and V. V. Tuchin, “In vitro and in vivo study of dye diffusion into the human skin and hair follicles,” J. Biomed. Opt. 7(3), 471–477 (2002).
E. Engel, R. Schraml, T. Maisch, K. Kobuch, B. König, R.-M. Szeimies, J. Hillenkamp, W. Bäumler, and R. Vasold, “Light-induced decomposition of indocyanine green,” Invest. Ophthalmol. Vis. Sci. 49, 1777–1783 (2008).
M. Sznitowska, “The influence of ethanol on permeation behavior of the porous pathway in the stratum corneum,” Int. J. Pharmacol. 137, 137-140 (1996).
A. K. Levang, K. Zhao, and J. Singh, “Effect of ethanol/propylene glycol on the in vitro percutaneous absorption of aspirin, biophysical changes and macroscopic barrier properties of the skin,” Int. J. Pharm. 181, 255-263 (1999).
C. A. Squier, M. J. Kremer, and P. W. Wertz, “Effect of ethanol on lipid metabolism and epidermal permeability barrier of skin and oral mucosa in the rat,” J. Oral Pathol. Med. 32, 595-599 (2003).
V. A. Dubrovskii, B. A. Dvorkin, I. Yu. Yanina, and V. V. Tuchin, “Photoaction upon adipose tissue cells in vitro,” Cell and Tissue Biology 5(5), 520-529 (2011).
B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts, and J. D. Watson, Molecular Biology of the Cell, 2nd edition, Vol. 1, Garland Publishing. Inc. New York London (1989).
A. L. Lehninger, Principles of Biochemistry, Vol. 2, Worth Publisher, Inc. (1982).
L. Stryer, Biochemistry, W. H. Freeman and Company, San Francisco (1981).
I. Yu. Yanina, N. A. Trunina, and V. V. Tuchin, “Photoinduced cell morphology alterations quantified within adipose tissues by spectral optical coherence tomography,” J. Biomed. Opt. 18(11), 111407 (2013).
R. K. Wang, and V. V. Tuchin, “Enhance light penetration in tissue for high resolution optical imaging techniques by the use of biocompatible chemical agents,” J. X-Ray Science and Technol. 10, 167-176 (2002).
R. K. Wang, and J. B. Elder, “Propylene glycol as a contrasting agent for optical coherence tomography to image gastrointestinal tissues,” Lasers Surg. Med. 30(3), 201-208 (2002).
H. Xiong, Z. Guo, C. Zeng, L. Wang, Y. He, and S. Liu, “Application of hyperosmotic agent to determine gastric cancer with optical coherence tomography ex vivo in mice,” J. Biomed. Opt. 14(2), 024029 (2009).
H. Q. Zhong, Z. Y. Guo, H. J. Wei, J. L. Si, L. Guo, Q. L. Zhao, C. C. Zeng, H. L. Xiong, Y. H. He, and S. H. Liu, “Enhancement of permeability of glycerol with ultrasound in human normal and cancer breast tissues in vitro using optical coherence tomography,” Laser Physics Letters 7(5), 388-395 (2010).
Z. Zhu, H. Wei, G. Wu, H. Yang, Y. He, and S. Xie, “Synergistic effect of hyperosmotic agents and sonophoresis on breast tissue optical properties and permeability studied with spectral domain optical coherence tomography,” J. Biomed. Opt. 17(8), 086002 (2012).
D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. G. van Leeuwen, “Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography,” Optics Express 12(19), 4353-4365 (2004).
P. Lee, W. Gao, and X. Zhang, “Performance of single-scattering model versus multiple-scattering model in the determination of optical properties of biological tissue with optical coherence tomography,” Appl. Opt. 49(18), 3538-3544 (2010).
K. V. Larin, and V. V. Tuchin, “Monitoring of glucose diffusion in epithelial tissues with optical coherence tomography,” Chap. 20 in Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues, V. V. Tuchin, Ed., pp. 635-668, Taylor & Francis Group LLC, CRC Press (2009).
T. Yamaguchi, N. Omatsu, E. Morimoto, H. Nakashima, K. Ueno, T. Tanaka, K. Satouchi, F. Hirose, and T. Osumi, “CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation,” J. Lipid Res. 48(5), 1078-1089 (2007).
J. Sharpe, “Optical projection tomography,” Annual Review of Biomedical Engineering 6, 209–228 (2004).
J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hesksher-Sorensen, R. Baldock, and D. Davidson, “Optical projection tomography as a tool for 3D microscopy and gene expression studies,” Science 296, 541–545 (2002).
T. Alanentalo, A. Asayesh, H. Morrison, C. E. Loren, D. Holmberg, J. Sharpe, and U. Ahlgren, “Tomographic molecular imaging and 3D quantification within adult mouse organs,” Nature Methods 4(1), 31–33 (2007).
T. Alanentalo, C. E. Loren, A. Larefalk, J. Sharpe, D. Holmberg, and U. Ahlgren, “High-resolution three-dimensional imaging of isletinfiltrate interactions based on optical projection tomography assessments of the intact adult mouse pancreas,” J. Biomed. Opt. 13(5), 054070 (2008).
H. Schneckenburger, R. Steiner, W. S. L. Strauss, K. Stock, and R. Sailer, “Fluorescence Technologies in Biomedical Diagnostics,” Chap. 15 in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin (Ed.), pp. 825-874, SPIE Press, PM107, Bellingham (2002).
H. Ashkenazi, Z. Malik, Y. Harth, and Y. Nitzan, “Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light,” FEMS Immunol. and Med. Microbiol. 35, 17-24 (2003).
Y. Kotoku, J. Kato, G. Akashi, Y. Hirai, and K. Ishihara, “Bactericidal effect of a 405-nm diode laser on Porphyromonas gingivalis,” Laser Physics Letters 6(5), 388-392 (2009).
K. König, G. Flemming, and R. Hibst, “Laser-induced autofluorescence spectroscopy of dental caries lesion,” Cell. Mol. Biol. 44, 1293-1300 (1998).
E. G. Borisova, T. T. Uzunov, and L. A. Avramov, “Early differentiation between caries and tooth demineralization using laser-induced autofluorescence spectroscopy,” Lasers Surg. Med. 34, 249-253 (2004).
E. Borisova, T. Uzunov, and L. Avramov, “Laser-induced autofluorescence study of caries model in vitro,” Lasers Med. Sci. 21(1), 34-41 (2006).
R. R. Alfano, W. Lam, H. J. Zarrabi, M. A. Alfano, J. Cordero, D. B. Tata, and C. E. Swenberg, “Human teeth with and without caries studied by laser scattering, fluorescence, and absorption spectroscopy,” IEEE J. Quantum Electronics QE-20(12), 1512-1516 (1984).
K. Konig, H. Schneckenburger, and R. Hibst, “Time-gated in vivo autofluorescence imaging of dental caries,” Cell. Mol. Biol. 45, 233-239 (1999).
E. Borisova, P. Troyanova, P. Pavlova, and L. Avramov, “Diagnostics of pigmented skin tumors based on laser-induced autofluorescence and diffuse reflectance spectroscopy,” Quantum Electronics 38(6), 597-605 (2008).
E. Borisova, E. Carstea, L. Cristescu, E. Pavlova, N. Hadjiolov, P. Troyanova, and L. Avramov, “Light-induced fluorescence spectroscopy and optical coherence tomography of basal cell carcinoma,” Journal of Innovative Optical Health Sciences 2(3), 261-268 (2009).
S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10(2), 024031 (2005).
A. Alimova, A. Katz, V. Sriramoju, Y. Budansky, A. A. Bykov, R. Zeylikovich, and R. R. Alfano, “Hybrid phosphorescence and fluorescence native spectroscopy for breast cancer detection,” J. Biomed. Opt. 12(1), 014004 (2007).
A. Gerger, S. Koller, T. Kern, C. Massone, K. Steiger, E. Richtig, H. Kerl, and J. Smolle, “Diagnostic applicability of in vivo confocal laser scanning microscopy in melanocytic skin tumors,” J. Invest. Dermatol. 124, 493–498 (2005).
S.-J. Tseng, Y.-H. Lee, Z.-H. Chen, H.-H. Lin, C.-Y. Lin, and S.-C. Tang, “Integration of optical clearing and optical sectioning microscopy for three-dimensional imaging of natural biomaterial scaffolds in thin sections,” J. Biomed. Opt. 14(4), 044004 (2009).
Y.-Y. Fu, C.-W. Lin, G. Enikolopov, E. Sibley, A.-S. Chiang, and S.-C. Tang, “Microtome-free 3-dimensional confocal imaging method for visualization of mouse intestine with subcellular-level resolution,” Gastroenterology 137(2), 453–465 (2009).
Y.-Y. Fu, and S.-C. Tang, “Optical clearing facilitates integrated 3D visualization of mouse ileal microstructure and vascular network with high definition,” Microvascular Res. 80, 512-521 (2010).
Y.-A. Liu, Y. Chen, A.-S. Chiang, S.-J. Peng, P. J. Pasricha, and S.-C. Tang, “Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and three-dimensional projection of the human enteric nervous system,” Neurogastroenterology & Motility 23, e446-e457 (2011).
Y.-Y. Fu, C.-H. Lu, C.-W. Lin, J.-H. Juang, G. Enikolopov, E. Sibley, A.-S. Chiang, and S.-C. Tang, “Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution,” J. Biomed. Opt. 15(4), 046018 (2010).
A.-S. Chiang, Y.-C. Liu, S.-L. Chiu, S.-H. Hu, C.-Y. Huang, and C.-H. Hsieh, “Three dimensional mapping of brain neuropils in the cockroach Diploptera punctata,” J. Comp. Neurol. 440, 1–11 (2001).
A. S. Chiang, “Aqueous tissue clearing solution,” US Patent, US6472216 (2002).
J. Huisken, and D. Y. Stainier, “Selective plane illumination microscopy techniques in developmental biology,” Development 136, 1963–1975 (2009).
K. Becker, N. Jährling, E. R. Kramer, F. Schnorrer, and H.-U. Dodt, “Ultramicroscopy: 3D reconstruction of large microscopical specimens,” J. Biophotonics 1, 36–42 (2008).
K. Becker, N. Jährling, S. Saghafi, R. Weiler, and H. U. Dodt, “Chemical clearing and dehydration of GFP expressing mouse brains,” PLOS One 7(3), e33916 (2012).
O. I. Efimova, and K. V. Anokhin, “Increase of optical permeability of isolated adult mouse brain structures,” Bull. Exp. Biol. Med. 147(1), 4–7 (2009).
A. Ertürk, K. Becker, N. Jährling, C. P. Mauch, C. D. Hojer, J. G. Egen, F. Hellal, F. Bradke, M. Sheng, and H. U. Dodt, “Three-dimensional imaging of solvent-cleared organs using 3DISCO,” Nature Protocols 7(11), 1983–1995 (2012).
R. G. M. Kolkman, E. Hondebrink, W. Steenbergen, and F. F. M. de Mul, “In vivo photoacoustic imaging of blood vessels using an extreme-narrow aperture sensor,” IEEE J. Sel. Top. Quantum Electron. 9, 343–346 (2003).
R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen, and T. G. van Leeuwen, “Photoacoustic determination of blood vessel diameter,” Phys. Med. Biol. 49, 4745–4756 (2004).
K. Maslov, G. Stoica, and L. H. Wang, “In vivo dark-field reflection-mode photoacoustic microscopy,” Opt. Lett. 30(6), 625-627 (2005).
A. A. Oraevsky, A. A. Karabutov, S. V. Solomatin, E. V. Savateeva, V. A. Andreev, Z. Gatalica, H. Singh, and R. D. Fleming, “Laser optoacoustic imaging of breast cancer in vivo,” Proc. SPIE 4256, 6–15 (2001).
H. F. Zhang, K. Maslov, and L. H. Wang, “In vivo imaging of subcutaneous structures using functional photoacoustic microscopy,” Nature Protocols 2(4), 797-804 (2007).
R. O. Esenaliev, I. V. Larina, K. V. Larin, D. J. Deyo, M. Motamedi, and D. S. Prough, “Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study,” Appl. Opt. 41, 4722–4731 (2002).
C. C. Harland, J. C. Bamber, B. A. Gusterson, and P. S. Mortime, “High frequency, high resolution B-scan ultrasound in the assessment of skin tumours,” Br. J. Dermatol. 128, 525-532 (1993).
Y. Zhou, J. J. Yao, and L. H. Wang, “Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth,” Opt. Lett. 38(14), 2592-2595 (2013).
K. M. Quan, G. B. Christison, H. A. MacKenzie, and P. Hodgson, “Glucose determination by a pulsed photoacoustic technique: an experimental study using a gelatin-based tissue phantom,” Phys. Med. Biol. 38, 1911–1922 (1993).
M. Kinnunen, and R. Myllyla, “Application of optical coherence tomography, pulsed photoacoustic technique, and time-of-flight technique to detect changes in the scattering properties of a tissue-simulating phantom,” J. Biomed. Opt. 13(2), 024005 (2008).
H. A. MacKenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg, and P. Rae, “Advances in photoacoustic noninvasive glucose testing,” Clin. Chem. 45, 1587–1595 (1999).
O. S. Khalil, “Non-invasive glucose measurement technologies: an update from 1999 to the dawn of the new millennium,” Diabetes Technol. Ther. 6, 660–697 (2004).
R. Cicchi, S. Sestini, V. De Giorgi, D. Massi, T. Lotti, and F. S. Pavone, “Nonlinear laser imaging of skin lesions,” J. Biophotonics 1(1), 62–73 (2008).
P. J. Campagnola, H. A. Clark, W. A. Mohler, A. Lewis, and L. M. Loew, “Second-harmonic imaging microscopy of living cells,” J. Biomed. Opt. 6(3), 277-286 (2001).
P. J. Campagnola, A. C. Millard, M. Terasaki, P. E. Hoppe, C. J. Malone, and W. A. Mohler, “Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues,” Biophys. J. 82, 493–508 (2002).
P. Bianchini, and A. Diaspro, “Three-dimensional (3D) backward and forward second harmonic generation (SHG) microscopy of biological tissues,” J. Biophotonics 1(6), 443-450 (2008).
V. Ajeti, O. Nadiarnykh, S. M. Ponik, P. J. Keely, K. W. Eliceiri, and P. J. Campagnola, “Structural changes in mixed Col I/Col V collagen gels probed by SHG microscopy: implications for probing stromal alterations in human breast cancer,” Biomedical Optics Express 2(8), 2307-2316 (2011).
T. Yasui, Y. Tohno, and T. Araki, “Characterization of collagen orientation in human dermis by two-dimensional second-harmonic-generation polarimetry,” J. Biomed. Opt. 9(2), 259–264 (2004).
H. G. Breunig, M. Weinigel, R. Buckle, M. Kellner-Hofer, J. Lademann, M. E. Darvin, W. Sterry, and K. Konig, “Clinical coherent anti-Stokes Raman scattering and multiphoton tomography of human skin with a femtosecond laser and photonic crystal fiber,” Laser Physics Letters 10, 025604 (2013).
G. Deka, W.-W. Wu, and F.-J. Kao, “In vivo wound healing diagnosis with second harmonic and fluorescence lifetime imaging,” J. Biomed. Opt. 18(6), 061222 (2013).
A. Ghazaryan, H. F. Tsai, G. Hayrapetyan, W.-L. Chen, Y.-F. Chen, M. Y. Jeong, C.-S. Kim, S.-J. Chen, and C.-Y. Dong, “Analysis of collagen fiber domain organization by Fourier second harmonic generation microscopy,” J. Biomed. Opt. 18(3), 031105 (2013).
R. Cicchi, L. Sacconi, and F. Pavone “Nonlinear Imaging of Tissues,” Chap. 20 in Handbook of Photonics for Biomedical Science, V. V. Tuchin (Ed.), pp. 509-545, CRC Press, Taylor & Francis Group, Boca Raton (2010).
M. Muller, J. A. Squier, T. Wilson, and G. Brakenhoff, “3D microscopy of transparent objects using third-harmonic generation,” J. Microsc. 191, 266–272 (1998).
G. Hall, K. W. Eliceiri, and P. J. Campagnola, “Simultaneous determination of the second-harmonic generation emission directionality and reduced scattering coefficient from three-dimensional imaging of thick tissues,” J. Biomed. Opt. 18(1), 116008 (2013).
M. Zimmerley, R. A. McClure, B. Choi, and E. O. Potma, “Following dimethyl sulfoxide skin optical clearing dynamics with quantitative nonlinear multimodal microscopy,” Appl. Opt. 48(10), D79–D87 (2009).
M. V. Schulmerich, J. H. Cole, K. A. Dooley, M. D. Morris, J. M. Kreider, and S. A. Goldstein, “Optical clearing in transcutaneous Raman spectroscopy of murine cortical bone tissue,” J. Biomed. Opt. 13(2), 021108 (2008).
D. Huang, W. Zhang, H. Zhong, H. Xiong, X. Guo, and Z. Guo, “Optical clearing of porcine skin tissue in vitro studied by Raman microspectroscopy,” J. Biomed. Opt. 17(1), 015004 (2012).
P. J. Caspers, A. C. Williams, E. A. Carter, H. G. M. Edwards, B. W. Barry, H. A. Bruining, and G. J. Puppels, “Monitoring the penetration enhancer dimethyl sulfoxide in human stratum corneum in vivo by confocal Raman spectroscopy,” Pharm. Res. 19(10), 1577–1580 (2002).
A. A. Angeluts, A. V. Balakin, M. G. Evdokimov, M. N. Esaulkov, M. M. Nazarov, I. A. Ozheredov, D. A. Sapozhnikov, P. M. Solyankin, O. P. Cherkasova, and A. P. Shkurinov, “Characteristic responses of biological and nanoscale systems in the terahertz frequency range,” Quantum Electronics 44(7), 614-632 (2014).
M. Nazarov, A. Shkurinov, V. V. Tuchin, and X.-C. Zhang, “Terahertz tissue spectroscopy and imaging,” Chapter 17 in Handbook of Photonics for Biomedical Science, V. V. Tuchin, Ed., pp. 592–617, CRC Press, London, Taylor & Francis Group (2010).
M. M. Nazarov, A. P. Shkurinov, E. A. Kuleshov, and V. V. Tuchin, “Terahertz time-domain spectroscopy of biological tissues,” Quantum Electronics 38(7), 647–654 (2008).
G. M. Png, J. W. Choi, B. W.-H. Ng, S. P. Mickan, D. Abbott, and X.-C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53, 3501–3517 (2008).
A. V. Borodin, V. Ya. Gayvoronsky, O. D. Kachkovsky, Ya. A. Prostota, A. V. Kargovskiі, M. M. Nazarov, D. A. Sapozhnikov, Yu. L. Slominskiі, I. N. Smirnova, and A. P. Shkurinov, “Structure sensitive changes in the terahertz absorption spectra of merocyanine dye derivatives,” Optics and Spectroscopy 107(4), 505-514 (2009).
C. S. Joseph, R. Patel, V. A. Neel, R. H. Giles, and A. N. Yaroslavsky, “Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions,” J. Biophotonics 7(5), 295-303 (2014).
S. J. Oh, J. Kang, I. Maeng, J.-S. Suh, Y.-M. Huh, S. Haam, and J.-H. SonMarch, “Nanoparticle-enabled terahertz imaging for cancer diagnosis,” Opt. Express 17(5), 3469–3475 (2009).
T. Yu, X. Wen, V. V. Tuchin, Q. Luo, and D. Zhu, “Quantitative analysis of dehydration in porcine skin for assessing mechanism of optical clearing,” J. Biomed. Opt. 16, 095002 (2011).
A. S. Kolesnikov, E. A. Kolesnikova, A. P. Popov, M. M. Nazarov, A. P. Shkurinov, and V. V. Tuchin, “In vitro terahertz monitoring of muscle tissue dehydration under the action of hyperosmotic agents,” Quantum Electronics 44(7), 633-640 (2014).
R. E. Beck, and J. S. Schultz, “Hindrance of solute diffusion within membranes as measured with microporous membranes of known pore geometry,” Biochem. Biophys. Acta 255, 272-303 (1972).
A. Kotyk, and K. Janacek, Membrane Transport: An Interdisciplinary Approach, Plenum Press, New York (1977).
I. H. Blank, J. Moloney, A. G. Emslie, I. and Apt, “The diffusion of water across the stratum corneum as a function of its water content,” J. Invest. Dermatol. 82, 188-194 (1984).
B. Sennhenn, K. Giese, K. Plamann, N. Harendt, and K. Kolmel, “In vivo evaluation of the penetration of topically applied drugs into human skin by spectroscopic methods,” Skin Pharmacol. 6, 152-160 (1993).
K. D. Peck, A.-H. Ghanem, and W. I. Higuchi, “Hindered diffusion of polar molecules through and effective pore radii estimates of intact and ethanol treated human epidermal membrane,” Pharmaceutical Research 11(9), 1306-1314 (1994).
T. Inamori, A.-H. Ghanem, W. I. Higuchi, and V. Srinivasan, “Macromolecule transport in and effective pore size of ethanol pretreated human epidermal membrane,” Int. J. Pharmaceutics 105, 113-123 (1994).
R. Bertram, and M. Pernarowski, “Glucose diffusion in pancreatic islets of Langerhans,” Biophys. J. 74, 1722-1731 (1998).
P. Gribbon, and T. E. Hardingham, “Macromolecular diffusion of biological polymers measured by confocal fluorescence recovery after photobleaching,” Biophys. J. 75, 1032-1039 (1998).
A. N. Yaroslavskaya, I. V. Yaroslavsky, C. Otto, G. J. Puppels, H. Guindam, G. F. J. M. Vrensen, J. Greve, and V. V. Tuchin, “Water exchange in human eye lens monitored by confocal Raman microspectroscopy,” Biophysics 43(1), 109-114 (1998).
E. E. Alanis, G. G. Romero, and C. C. Martinez, “Interferometric measurement of diffusion coefficients through a scanning laser beam,” Opt. Eng. 39(3), 744-750 (2000).
S. Papadopoulos, K. D. Jurgens, and G. Gros, “Protein diffusion in living skeletal muscle fibers: dependence on protein size, fiber type, and contraction,” Biophys. J. 79, 2084-2094 (2000).
A. E. Kamholz, E. A. Schilling, and P. Yager, “Optical measurement of transverse molecular diffusion in a microchannel,” Biophys. J. 80, 1967-1972 (2001).
S. S. Olmsted, J. L. Padgett, A. I. Yudin, K. J. Whaley, T. R. Moench, and R. A. Cone, “Diffusion of macromolecules and virus-like particles in human cervical mucus,” Biophys. J. 81, 1930-1937 (2001).
J. Kusba, L. Li, I. Gryczynski, G. Piszczek, M. Johnson, and J. R. Lakowicz, “Lateral diffusion coefficients in membranes measured by resonance energy transfer and a new algorithm for diffusion in two dimensions,” Biophys. J. 82, 1358-1372 (2002).
W. Heller, “Remarks on refractive index mixture rules,” J. Phys. Chem. 69(4), 1123–1129 (1965).
J. S. Maier, S. A. Walker, S. Fantini, M. A. Franceschini, and E. Gratton, “Possible correlation between blood glucose concentration and the reduced scattering coefficient of tissues in the near infrared,” Opt. Lett. 19(24), 2062-2064 (1994).
M. Kohl, M. Esseupreis, and M. Cope, “The influence of glucose concentration upon the transport of light in tissue-simulating phantoms,” Phys. Med. Biol. 40, 1267-1287 (1995).
J. M. Schmitt, and G. Kumar, “Optical scattering properties of soft tissue: a discrete particle model,” Appl. Opt. 37(13), 2788-2797 (1998).
W. H. Press, S. A. Tuekolsky, W. T. Vettering, and B. P. Flannery, Numerical recipes in C: the art of scientific computing, Cambridge: Cambridge University Press (1992).
I. S. Grigoriev, and E. Z. Meylikhov (Eds.), Physical Values: Handbook, Moscow: EnergoAtomIzdat (1991).
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