Photosensitizing properties of supramolecular systems based on chlorin e6

Inna V. Klimenko (Login required)
Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russia

Anton V. Lobanov
Semenov Institute of Chemical Physics of Russian Academy of Sciences, Moscow, Russia


Paper #3122 received 2016.11.20; accepted for publication 2016.12.29; published online 2016.12.31.

DOI: 10.18287/JBPE16.02.040310

Abstract

The novel supramolecular systems based on chlorine e6 (Ce6) are presented, and their optical absorption and fluorescence have been investigated. The influence of different excipients as poly-N-vinylpyrrolidone (PVP), polyethyleneglycol (PEG), bovine serum albumin (BSA), chitosan, Triton X-100 (TX-100) on spectral characteristics of these systems has been studied. The obtained spectral-fluorescence characteristics of Ce6-PVP, Ce6-PEG, Ce6-BSA, Ce6-TX-100 indicate disaggregation of chlorine e6 molecules and their consecutive interaction with excipients in solutions and formation of molecular associates and molecular complexes. The system Ce6-chitosan is characterized by aggregation of pigments in solution that reduces photochemical activity of a photosensitizer. The fluorescence quantum yield jk of mentioned above supramolecular systems has been calculated. The results can be useful during the new method of controlled aggregation of photosensitizers as a part of supramolecular complexes development as well as for the purposes of new medicines of predictable photodynamic activity creation.

Keywords

chlorin е6; photodynamic therapy; supramolecular systems; spectral characteristics; optical absorption; fluorescence

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